{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T16:39:19Z","timestamp":1777739959145,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:00:00Z","timestamp":1628640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100013211","name":"Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences","doi-asserted-by":"publisher","award":["1610072020006"],"award-info":[{"award-number":["1610072020006"]}],"id":[{"id":"10.13039\/501100013211","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Inflammation\u2010related diseases present a significant public health problem. Ginger is a flavoring spice and medicinal herb with anti\u2010inflammatory activity. This study investigated the preventive effects of ginger extract (GE) and its main bioactive component, 6\u2010gingerol (6G), on lipopolysaccharide (LPS)\u2010induced intestinal barrier dysfunction and liver injury in mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>GE and 6G were orally administered to mice for seven consecutive days before LPS administration. After 24\u2009h, the mice were sacrificed. GE and 6G were found to significantly reverse LPS\u2010induced inflammation in the mouse ileum by modifying the NF\u2010\u03baB pathway. They also alleviated apoptosis in the ileum by downregulating Bax and cytochrome c gene expression and by inhibiting the caspase\u20103 pathway. Through the aforementioned mechanisms, GE and 6G restored the intestinal barrier by increasing ZO\u20101 and claudin\u20101 protein expressions. Gut\u2010derived LPS induced inflammation and apoptosis in the liver; these effects were markedly reversed through GE and 6G treatment. 6G was the most abundant component in GE, as evidenced through liquid chromatography\u2013mass spectrometry, and accounted for &gt;50% of total gingerols and shogaols in GE.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The current results support the use of GE and 6G as dietary supplements to protect against gut\u2010derived endotoxemia\u2010associated inflammatory response and disorders. \u00a9 2021 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.11442","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T09:57:23Z","timestamp":1627293443000},"page":"1066-1075","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Ginger and 6\u2010gingerol prevent lipopolysaccharide\u2010induced intestinal barrier damage and liver injury in mice"],"prefix":"10.1002","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7077-4659","authenticated-orcid":false,"given":"Xiao\u2010Xuan","family":"Guo","sequence":"first","affiliation":[{"name":"Institute of Quality Standard and Testing Technology for Agro\u2010products, Chinese Academy of Agricultural Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun\u2010Dan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Quality Standard and Testing Technology for Agro\u2010products, Chinese Academy of Agricultural Sciences  Beijing China"},{"name":"College of Food Science and Nutritional Engineering, China Agricultural University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian\u2010Cai","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Quality Standard and Testing Technology for Agro\u2010products, Chinese 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