{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T05:12:24Z","timestamp":1768281144725,"version":"3.49.0"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T00:00:00Z","timestamp":1628553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006461","name":"Agencia de Innovaci\u00f3n y Desarrollo de Andaluc\u00eda","doi-asserted-by":"publisher","award":["P11\u2010AGR\u20107648"],"award-info":[{"award-number":["P11\u2010AGR\u20107648"]}],"id":[{"id":"10.13039\/501100006461","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Iron deficiency and iron overload can affect the normal functioning of the innate and adaptive immune responses. Fermented milk products may enhance immune functions, but little is known about the effect of fermented milks on modulation of the immune response during iron deficiency anemia and recovery with normal or high dietary iron intake. Eighty male Wistar rats were randomly assigned to a control group fed a standard diet or to an anemic group fed a diet deficit in iron. Control and anemic groups were fed for 30\u2009days with diets based on a fermented goat's or cow's milk product, with normal iron content or iron overload.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In general, during anemia recovery lectin and alternative complement pathway activity and lactoferrin decreased, because it improves iron homeostasis, which is critically important in immune system functions. Fermented goat's milk diet enhanced immune function during iron deficiency recovery, suppressed oxidant\u2010induced eotaxin and fractalkine expression due to the concurrent reduction of free radical production and pro\u2010inflammatory cytokines, and decreased monocyte chemoattractant protein\u20101 and monocyte migration and adhesion. The increase in interferon\u2010\u03b3 can confer immunological colonization of gut microbiota and downregulate inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Fermented goat's milk consumption enhances immune function, modifying complement pathway activity and decreasing pro\u2010inflammatory cytokines as well as lactoferrin concentration, due to the improvement of iron homeostasis, which is critically important in the normal function of the immune system. \u00a9 2021 The Authors. <jats:italic>Journal of The Science of Food and Agriculture<\/jats:italic> published by John Wiley &amp; Sons Ltd on behalf of Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.11448","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T12:40:21Z","timestamp":1627648821000},"page":"1114-1123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Fermented goat's milk modulates immune response during iron deficiency anemia recovery"],"prefix":"10.1002","volume":"102","author":[{"given":"Mar\u00eda","family":"Garc\u00eda\u2010Burgos","sequence":"first","affiliation":[{"name":"Department of Physiology University of Granada  Granada Spain"},{"name":"Institute of Nutrition and Food Technology \u2018Jos\u00e9 Mataix Verd\u00fa\u2019 University of Granada  Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9690-7851","authenticated-orcid":false,"given":"Jorge","family":"Moreno\u2010Fernandez","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Granada  Granada Spain"},{"name":"Institute of Nutrition and Food Technology \u2018Jos\u00e9 Mataix Verd\u00fa\u2019 University of Granada  Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"D\u00edaz\u2010Castro","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Granada  Granada Spain"},{"name":"Institute of Nutrition and Food Technology \u2018Jos\u00e9 Mataix Verd\u00fa\u2019 University of Granada  Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jos\u00e9","family":"M Alf\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Granada  Granada Spain"},{"name":"Institute of Nutrition and Food Technology \u2018Jos\u00e9 Mataix Verd\u00fa\u2019 University of Granada  Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7627-8760","authenticated-orcid":false,"given":"Inmaculada","family":"L\u00f3pez\u2010Aliaga","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Granada  Granada Spain"},{"name":"Institute of Nutrition and Food Technology \u2018Jos\u00e9 Mataix Verd\u00fa\u2019 University of Granada  Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1215361"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.03160"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105017"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-018-0990-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.2.568S"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980008002401"},{"key":"e_1_2_8_8_1","unstructured":"KuvibidilaSR Effect of iron deficiency anemia on the immune function. 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