{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:34:00Z","timestamp":1789659240888,"version":"4.0.1"},"reference-count":63,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The consumption of dietary Maillard reaction products (MRPs) might lead to positive or negative effects on health. The digestibility of half\u2010fin anchovy hydrolysates\/glucose MRPs (HAHp(9.0)\u2010G MRPs) was therefore determined. The intestinal microbiota modulation of HAHp(9.0)\u2010G MRPs in mice was also evaluated after administration for 14\u2009days (1\u00a0g\u2009kg<jats:sup>\u22121<\/jats:sup>\u2022bodyweight).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Different levels of digestibility of MRPs of fructosamine and advanced glycation products of N<jats:sup>\u03b5<\/jats:sup>\u2010carboxymethyllysine were detected in HAHp(9.0)\u2010G MRPs during simulated gastrointestinal digestion. An increased relative proportion of soluble fluorescent melanoidins (SFMs) was observed during gastric digestion as compared to that in the original HAHp(9.0)\u2010G MRPs, followed by decreases in SFMs in intestinal digestion. After feeding with HAHp(9.0)\u2010G MRPs for 14\u2009days, increased goblet cells were observed in the ileum regions of female and male mice. High\u2010throughput 16S ribosomal RNA gene sequencing of fecal samples revealed that HAHp(9.0)\u2010G MRPs administration increased the density of the phylum <jats:italic>Bacteriodetes<\/jats:italic> and reduced the density of the phylum <jats:italic>Firmicutes<\/jats:italic> in male mice. By comparison, a relatively higher density of members of the phylum <jats:italic>Saccharibacteria<\/jats:italic> was observed in female mice. A consistent increase in the abundance of <jats:italic>Bacteroidales_S24\u20107_group_norank<\/jats:italic> was found in female and male groups fed with HAHp(9.0)\u2010G MRPs. Female and male mice treated with HAHp(9.0)\u2010G MRPs also showed higher levels of propionic and butyric acids in feces than their corresponding controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Half\u2010fin anchovy hydrolysates\/glucose MRPs can be partly hydrolyzed in the simulated gastrointestinal digestion system. Treatment with HAHp(9.0)\u2010G MRPs induced sex\u2010related differences in bacterial abundance and diversity in mice; however, the up\u2010regulation of anti\u2010inflammatory activity was predicted in both female and male mice. \u00a9 2021 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.11600","type":"journal-article","created":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T00:30:00Z","timestamp":1635035400000},"page":"2584-2597","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Digestive properties of half\u2010fin anchovy hydrolysates\/glucose <scp>M<\/scp>aillard reaction products and modulation effects on intestinal microbiota"],"prefix":"10.1002","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1324-777X","authenticated-orcid":false,"given":"Ru","family":"Song","sequence":"first","affiliation":[{"name":"Key Laboratory of Health Risk Factors for Seafood of 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