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Dietary functional foods probably could help to improve salt\u2010induced hypertension. In this study, Dahl salt\u2010sensitive (DSS) rats were used to investigate their metabolic differences from those of salt\u2010resistant SS.13<jats:sup>BN<\/jats:sup> rats and determine whether dietary protein\u2010rich almonds could ameliorate salt\u2010induced elevation of blood pressure in DSS rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>After high\u2010salt intake, the systolic blood pressure and mean arterial pressure of the DSS rats increased dramatically. Metabolomics analysis indicated abnormal amino acid metabolism in their kidneys. Their renal nitric oxide (NO) content and nitric oxide synthase activity decreased significantly after high\u2010salt diet. Oxidative stress also occurred in DSS rats. After the DSS rats received almond supplementation, the levels of various amino acids in their kidney increased, and renal arginine and NO contents were upregulated. Their renal hydrogen peroxide and malonaldehyde levels decreased, whereas renal catalase, superoxide dismutase and glutathione peroxidase activities and glutathione levels increased.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The renal abnormal amino acid metabolism of DSS rats contributed to the impaired NO production in response to high\u2010salt intake. Together with salt\u2010induced oxidative stress, high\u2010salt diet intake ultimately led to an increase in the blood pressure of DSS rats. Protein\u2010rich almond supplementation might prevent the development of salt\u2010induced hypertension by restoring arginine and NO regeneration and alleviating salt\u2010induced oxidative stress. \u00a9 2021 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.11611","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T03:04:00Z","timestamp":1635390240000},"page":"2710-2722","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effects of almonds on ameliorating salt\u2010induced hypertension in dahl salt\u2010sensitive rats"],"prefix":"10.1002","volume":"102","author":[{"given":"Li","family":"Zeng","sequence":"first","affiliation":[{"name":"Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology Xi'an Jiaotong University  Xi'an 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