{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T02:52:40Z","timestamp":1784775160456,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2023,5,14]],"date-time":"2023-05-14T00:00:00Z","timestamp":1684022400000},"content-version":"am","delay-in-days":346,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T00:00:00Z","timestamp":1654128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T00:00:00Z","timestamp":1654128000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006190","name":"Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Aging causes decreased antioxidant capacity and chronic inflammation and may even elevate cancer risks. Previous studies reported that flaxseed oil (FO) can alleviate age\u2010related diseases, including improving alcoholic liver disease, atherosclerosis and diabetes. However, whether the intestinal microbiota accountable for this alleviation is still unknown. This study aims to study the antioxidant effects of FO in an aging rat model and the underlying mechanism between the intestinal microbiota and aging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Our results presented that serum and liver antioxidant capacities in FO group were up\u2010regulated, and liver inflammation in FO group was reduced. The 16S rDNA sequencing showed that FO regulated the microbial community, including up\u2010regulation of four families of Lactobacillus and six families of Clostridium. In addition, FO had also adjusted the relative abundance of several genera such as\n                      <jats:italic>Ruminococcaceae_UCG\u2010005<\/jats:italic>\n                      and\n                      <jats:italic>Prevotella_9<\/jats:italic>\n                      , which may be the key bacteria associated with the aging process. Colonic transcriptome analysis showed that there were 1679 differentially expressed genes (DEGs) in the Model group and the FO group (134 up\u2010regulated and 1545 down\u2010regulated). Gene set enrichment analysis (GSEA) revealed FO down\u2010regulates the expression of the upstream genes\n                      <jats:italic>Ptprc<\/jats:italic>\n                      ,\n                      <jats:italic>Lck<\/jats:italic>\n                      ,\n                      <jats:italic>Zap70<\/jats:italic>\n                      ,\n                      <jats:italic>Lat<\/jats:italic>\n                      and\n                      <jats:italic>Lcp2<\/jats:italic>\n                      in the T cell receptor signaling pathway.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>In conclusion, FO improved antioxidant capacity and reduced intestinal microbial disturbances caused by aging damage, indicating that dietary FO has the potential to fight aging damage. This study provides a more comprehensive view of dietary intervention to improve aging. \u00a9 2022 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.12010","type":"journal-article","created":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T03:54:31Z","timestamp":1652500471000},"page":"6432-6442","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Flaxseed oil ameliorates aging in\n                    <scp>d<\/scp>\n                    \u2010galactose induced rats\n                    <i>via<\/i>\n                    altering gut microbiota and mitigating oxidative damage"],"prefix":"10.1002","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0953-4477","authenticated-orcid":false,"given":"Xiaoyan","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Food Science and Engineering Jinan University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Food Science and Engineering Jinan University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Food Science and Engineering Jinan University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Food Science and Engineering Jinan University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Food Science and Engineering Jinan University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xichun","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Food Science and Engineering Jinan University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12062-018-9225-7"},{"key":"e_1_2_8_3_1","article-title":"Blood flow restriction exercises: promoting healthy ageing","volume":"30","author":"Rauf S","year":"2021","journal-title":"J Coll Physicians Surg Pak"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13524"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2016.04.009"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202666"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2021.03.020"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.641315"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/11.3.298"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.02.001"},{"key":"e_1_2_8_11_1","first-page":"48","article-title":"Inflammaging: inflammation and oxidative stress as a cause of aging and cognitive decline","author":"Pereverzev AP","year":"2021","journal-title":"Med Coun"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glu057"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2011.03.004"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2014.04.001"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3RI0620-405RR"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.219691"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2017.1331363"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2008.01.004"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.2217\/clp.11.36"},{"key":"e_1_2_8_20_1","first-page":"87","article-title":"Dietary Flaxseed Oil supplementation improves the oxidant\/antioxidant status in obese aged rats","volume":"3","author":"Ahlem L","year":"2013","journal-title":"Int J Med Pharmaceut Sci"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2017.11.031"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2MO00041E"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/09637486.2017.1343286"},{"key":"e_1_2_8_24_1","first-page":"41","article-title":"Comparative study of quality changes in deep frying of youtiao using flaxseed oil and palm olein","volume":"46","author":"Xu Z","year":"2021","journal-title":"China Oils Fats"},{"key":"e_1_2_8_25_1","first-page":"64","article-title":"The uncertainty of measurement of determination of fatty acid composition soybean oil by GC","volume":"04","author":"Ping L","year":"2021","journal-title":"Farm Prod Proces"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-019-09837-y"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cryobiol.2020.04.010"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2020.109811"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2604"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043200"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.01.010"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2009.04.007"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni744"},{"key":"e_1_2_8_34_1","article-title":"T cell receptor signal transduction in T lymphocytes","volume":"2012","author":"Gorentla BK","year":"2012","journal-title":"J Clin Cell Immunol"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.042762"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.290635.116"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2784"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00586"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201901024"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-019-0256-8"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9FO00189A"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.03.011"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-018-5202-z"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.8b02166"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.12.046"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2017.01.001"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8FO01768A"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11061297"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7RA07651G"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.3233\/NHA-170030"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10213"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2016.04.007"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaw8151"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-018-0020-8"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540105.2020.1761302"}],"container-title":["Journal of the Science of Food and Agriculture"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jsfa.12010","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jsfa.12010","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/jsfa.12010","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jsfa.12010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T04:45:42Z","timestamp":1775277942000},"score":1,"resource":{"primary":{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/10.1002\/jsfa.12010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,2]]},"references-count":54,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1002\/jsfa.12010"],"URL":"https:\/\/doi.org\/10.1002\/jsfa.12010","archive":["Portico"],"relation":{},"ISSN":["0022-5142","1097-0010"],"issn-type":[{"value":"0022-5142","type":"print"},{"value":"1097-0010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,2]]},"assertion":[{"value":"2022-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}