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Curcumin is a kind of natural polyphenol compound for which various beneficial biological functions exist, including being an anti\u2010inflammatory, antioxidant, and antiviral. The aim of this work was to investigate the mechanism of curcumin\u2010alleviated lipopolysaccharide (LPS)\u2010induced lung damage by the nuclear erythroid 2\u2010related factor 2 (Nrf2)\u2010antioxidant reaction element (ARE) and nuclear factor kappa B (NF\u2010\n                      <jats:italic>\u03ba<\/jats:italic>\n                      B) signaling pathway in ducks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In total, 450 one\u2010day\u2010old male specific pathogen\u2010free ducks were randomly assigned into three dietary treatments: CON, basal diet; LPS, basal diet + LPS treatment; LPS\u2009+\u2009CUR, basal diet + LPS\u2009+\u2009500\u2009mg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      of curcumin. At the end of the experiment (21\u2009days), ducks in LPS treatment were challenged with 5\u00a0mg LPS per kilogram of body weight and the other two treatments were injected with the same dose of phosphate\u2010buffered saline solution. The results showed that LPS caused acute inflammation, oxidation stress, and lung injury. Dietary addition of curcumin significantly relieved the oxidation stress and inflammation parameters. Moreover, the results showed that remission may be through the signaling pathways of both Nrf2\u2010ARE and NF\u2010\n                      <jats:italic>\u03ba<\/jats:italic>\n                      B.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      In conclusion, dietary supplementation of 500\u2009mg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      of curcumin exhibited a lung\u2010protective effect in ducks. This experiment broadens the mode of metabolism actions of curcumin in the target organs and provides an insight for the application of curcumin in waterfowl feed. \u00a9 2022 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.12027","type":"journal-article","created":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T05:23:19Z","timestamp":1653110599000},"page":"6603-6611","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Curcumin alleviated\n                    <scp>lipopolysaccharide\u2010induced<\/scp>\n                    lung injury via regulating the\n                    <scp>Nrf2\u2010ARE<\/scp>\n                    and\n                    <scp>\n                      NF\u2010\n                      <i>\u03ba<\/i>\n                      B\n                    <\/scp>\n                    signaling pathways in ducks"],"prefix":"10.1002","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0135-2254","authenticated-orcid":false,"given":"Xiao","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Animal Nutrition, College of Animal Science and Technology, Northeast Agricultural University  Harbin 150030 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei Yue","family":"Guan","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition, College of Animal Science and Technology, Northeast Agricultural University  Harbin 150030 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Ting","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition, College of Animal Science and Technology, Northeast Agricultural University  Harbin 150030 People's Republic of 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