{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:55Z","timestamp":1786978255164,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2022,12]]},"abstract":"Abstract<\/jats:title>\n \n BACKGROUND<\/jats:title>\n \n Polysaccharides and probiotics can play an outstanding role in the treatment of liver disease by regulating gut microbiota. Recently, the combined therapeutic effect of probiotics and polysaccharides has attracted the attention of researchers.\n Houttuynia cordata<\/jats:italic>\n polysaccharide (HCP) combined with\n Lactiplantibacillus plantarum<\/jats:italic>\n P101 was used to prevent carbon tetrachloride (CCl\n 4<\/jats:sub>\n )\u2010induced acute liver injury (ALI) in mice, and its effect on gut microbiota regulation was explored.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Results showed that, in mice, HCP combined with\n L. plantarum<\/jats:italic>\n P101 significantly alleviated oxidative stress and inflammatory injury in the liver by activating Nrf2 signals and inhibiting NF\u2010\n \u03ba<\/jats:italic>\n B signals. The analysis of gut microbiota revealed that the combination of HCP and\n L. plantarum<\/jats:italic>\n P101 increased the abundance of beneficial bacteria such as\n Alloprevotella<\/jats:italic>\n ,\n Roseburia,<\/jats:italic>\n and\n Akkermansia<\/jats:italic>\n , but reduced that of the pro\u2010inflammatory bacteria\n Alistipes<\/jats:italic>\n ,\n Enterorhabdus<\/jats:italic>\n ,\n Anaerotruncus,<\/jats:italic>\n and\n Escherichia\u2010Shigella<\/jats:italic>\n . Correlation analysis also indicated that the expression of\n Nrf2<\/jats:italic>\n and\n TLR4<\/jats:italic>\n \/\n NF\u2010\u03baB<\/jats:italic>\n was connected to the changes in gut microbiota composition.\n Houttuynia cordata<\/jats:italic>\n polysaccharide combined with\n L. plantarum<\/jats:italic>\n P101 can regulate the gut microbiota and then mediate the gut\u2010liver axis to activate the antioxidant pathway and inhibit inflammatory responses, thereby alleviating CCl\n 4<\/jats:sub>\n \u2010induced ALI.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n Our study provided a new perspective on the use of polysaccharides combined with probiotics in the treatment of liver disease. \u00a9 2022 Society of Chemical Industry.<\/jats:p>\n 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