{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T08:54:05Z","timestamp":1782809645712,"version":"3.54.5"},"reference-count":55,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T00:00:00Z","timestamp":1656892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Feruloyl oligosaccharides (FOs), the ferulic acid ester of oligosaccharides, may possess the physiological functions of both ferulic acid and oligosaccharides, including antioxidative activity and gut microbiota modulation capacity. The present study aimed to investigate whether FOs could regulate the intestinal antioxidative capacity of rats by modulating the MAPKs\/Nrf2 signaling pathway and gut microbiota. Thirty Wistar rats were randomly divided into five groups. Rats received a standard diet and were gavaged once daily with 0.85% normal saline, 100\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup> body weight vitamin C or FOs solution at doses of 20, 40 and 80\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup> body weight for 21\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>FOs strengthened the antioxidative capacity of the jejunum, as indicated by increased in contents of catalase, superoxide dismutase and glutathione peroxidase, as well as glutathione. Moreover, FOs administration upregulated the mRNA expression level of antioxidant\u2010related genes (glutamate\u2010cysteine ligase catalytic subunit, glutamate\u2010cysteine ligase modifier subunit and heme oxygenase\u20101) in the jejunum. Increases in phosphorylation levels of Nrf2, p38 and JNK were also observed. Administration with 40\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup> FOs altered the structure and composition of the cecal microbiota, which was indicated by the increased the relative abundances of Actinobacteria, Proteobacteria and Acidobacteriota, and the decreased the relative abundances of Firmicutes, <jats:italic>Lachnospiraceae_NK4A136_group<\/jats:italic> and <jats:italic>Blautia.<\/jats:italic> Furthermore, Spearman correlation analysis revealed that the altered cecal microbiota closely correlated with jejunal antioxidative capacity of rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>FOs could be used as an antioxidant for gut heath improvement through modulating the p38\/JNK\u2010Nrf2 signaling pathway and gut microbiota. \u00a9 2022 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.12061","type":"journal-article","created":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T05:29:31Z","timestamp":1654925371000},"page":"6992-7002","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Regulation of wheat bran feruloyl oligosaccharides in the intestinal antioxidative capacity of rats associated with the p38\/<scp>JNK\u2010Nrf2<\/scp> signaling pathway and gut microbiota"],"prefix":"10.1002","volume":"102","author":[{"given":"Wenwen","family":"Wang","sequence":"first","affiliation":[{"name":"College of Animal Science Inner Mongolia Agricultural University  Hohhot China"},{"name":"Inner Mongolia Herbivorous Livestock Feed Engineering and Technology Research Center  Hohhot 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