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The aim of this study was to investigate the preventive effects of dietary curcumin (CUR) on LPS toxicity in the duck ileum. The duck diet was supplemented with CUR (0.5\u2009g\u2009kg<jats:sup>\u22121<\/jats:sup>) for 28\u2009days, while the birds were injected with LPS (0.5\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup> body weight per injection, administered as seven injections in the last week of the experimental period).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>LPS significantly decreased the ileal villus\u2010to\u2010crypt ratio in the non\u2010supplemented CUR group. Dietary CUR alleviated LPS\u2010induced morphological damage to the ileum. Moreover, dietary CUR alleviated oxidative stress by increasing the levels of total superoxide dismutase (T\u2010SOD) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and glutathione <jats:italic>S<\/jats:italic>\u2010transferase (GST) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and decreasing the production of malonic dialdehyde (MDA) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) in control ducks and LPS\u2010challenged ducks. Dietary CUR significantly inhibited the LPS\u2010induced massive production of inflammatory factors (IL\u20101\u03b2, IL\u20106, and TNF\u2010\u03b1) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). CUR induced the inhibition of TLR4 and activation of Nrf2 to reduce the expression of inflammation\u2010related genes (TLR4, NF\u2010\u03baB, IKK, TXNIP, NLRP3, caspase\u20101, IL\u20101\u03b2, IL\u20106, and TNF\u2010\u03b1). Moreover, dietary CUR ameliorated the decrease in claudin\u20101 and occludin expression (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and improved ZO\u20101 expression in the duck ileum (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>In conclusion, dietary CUR has beneficial effects on LPS\u2010induced ileal damage, oxidative damage, and inflammatory response by inhibiting the TLR\/NF\u2010\u03baB and activating the Nrf2 signaling pathways in ducks. This study provides valuable information regarding the therapeutic uses of CUR in duck ileitis. \u00a9 2022 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.12252","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T14:44:11Z","timestamp":1665240251000},"page":"1550-1560","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Curcumin: a potential exogenous additive for the prevention of <scp>LPS<\/scp>\u2010induced duck ileitis by the alleviation of inflammation and oxidative stress"],"prefix":"10.1002","volume":"103","author":[{"given":"Hao","family":"Yang","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Nutrition Institute of Animal Nutrition, Northeast Agricultural University  Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunting","family":"Yu","sequence":"additional","affiliation":[{"name":"Laboratory of 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