{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T23:03:00Z","timestamp":1768777380771,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["Serra H\u00fanter"],"award-info":[{"award-number":["Serra H\u00fanter"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["248 \/10.13039\/501100011033 (AEI\/FEDER)"],"award-info":[{"award-number":["248 \/10.13039\/501100011033 (AEI\/FEDER)"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007512","name":"Universitat Rovira i Virgili","doi-asserted-by":"publisher","award":["Mart\u00ed Franqu\u00e8s"],"award-info":[{"award-number":["Mart\u00ed Franqu\u00e8s"]}],"id":[{"id":"10.13039\/501100007512","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2023,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>It has been previously shown that acutely administered insect <jats:italic>Alphitobius diaperinus<\/jats:italic> protein increases food intake in rats and modifies the <jats:italic>ex vivo<\/jats:italic> enterohormone secretory profile differently than beef or almond proteins. In this study, we aimed to evaluate whether these effects could be maintained for a longer period and determine the underlying mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>We administered two different insect species to rats for 26\u2009days and measured food intake at different time points. Both insect species increased food intake in the first week, but the effect was later lost. Glucagon\u2010like peptide 1 (GLP\u20101) and ghrelin were measured in plasma and <jats:italic>ex vivo<\/jats:italic>, and no chronic effects on their secretion or desensitization were found. Nevertheless, digested <jats:italic>A. diaperinus<\/jats:italic> acutely modified GLP\u20101 and ghrelin secretion <jats:italic>ex vivo<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Our results suggest that increases in food intake could be explained by a local ghrelin reduction acting in the small intestine. \u00a9 2022 The Authors. <jats:italic>Journal of The Science of Food and Agriculture<\/jats:italic> published by John Wiley &amp; Sons Ltd on behalf of Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.12305","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:24:52Z","timestamp":1667435092000},"page":"1660-1667","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Administration of <scp><i>Alphitobius diaperinus<\/i><\/scp> or <scp><i>Tenebrio molitor<\/i><\/scp> before meals transiently increases food intake through enterohormone regulation in female rats"],"prefix":"10.1002","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1567-0018","authenticated-orcid":false,"given":"Alba","family":"Migu\u00e9ns\u2010G\u00f3mez","sequence":"first","affiliation":[{"name":"Departament de Bioqu\u00edmica i Biotecnologia MoBioFood Research Group, Universitat Rovira i Virgili  Tarragona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Sierra\u2010Cruz","sequence":"additional","affiliation":[{"name":"Departament de Bioqu\u00edmica i Biotecnologia MoBioFood Research Group, Universitat Rovira i Virgili  Tarragona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Seg\u00fa","sequence":"additional","affiliation":[{"name":"Departament de Bioqu\u00edmica i Biotecnologia MoBioFood Research Group, Universitat Rovira i Virgili  Tarragona 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