{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:50:22Z","timestamp":1791823822261,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31801918"],"award-info":[{"award-number":["31801918"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31901693"],"award-info":[{"award-number":["31901693"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2023,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p><jats:italic>Cordyceps militaris<\/jats:italic> is an edible and medicinal fungus, and its polysaccharides are among its main pharmacological components. They can display immunomodulation, anti\u2010oxidation, anti\u2010inflammation, anti\u2010hypolipidemic, and other functions. The anti\u2010obesity effect of <jats:italic>C. militaris<\/jats:italic> polysaccharides (CMP) is not yet fully understood, however.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In this study, a CMP diet intervention was applied over a 4\u2009week period to mice with obesity induced by a high\u2010fat diet (HFD), followed by profiling of obesity\u2010induced dyslipidemia, low\u2010grade inflammation, and gut dysbiosis. The results suggested that CMP could significantly reduce HFD\u2010induced obesity, alleviate obesity\u2010induced hyperlipidemia and insulin resistance, and ameliorate systemic inflammation, showing a promising ability to protect mice from obesity. Further analyses revealed that CMP could regulate obesity\u2010induced gut dysbiosis by restoring the phylogenetic diversity of gut microbiota. It could also increase the relative abundance of short\u2010chain fatty acid (SCFA)\u2010producing bacteria, while down\u2010regulating the level of bacteria that were positively related to the development of obesity. A correlation analysis showed that <jats:italic>Helicobacter<\/jats:italic>, <jats:italic>Allobaculum<\/jats:italic>, Clostridium XVIII, <jats:italic>Parabacteroides<\/jats:italic>, <jats:italic>Ligilactobacillus<\/jats:italic>, <jats:italic>Faecalibaculum<\/jats:italic>, <jats:italic>Adlercreutzia<\/jats:italic>, and <jats:italic>Mediterraneibacter<\/jats:italic> were positively related to obese phenotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>This study highlights the potential of CMP as a prebiotic agent to protect obese individuals from metabolic disorders and gut dysbiosis. \u00a9 2022 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.12409","type":"journal-article","created":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T04:05:02Z","timestamp":1672027502000},"page":"1885-1894","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["<i>Cordyceps 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