{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T07:20:52Z","timestamp":1788852052566,"version":"build-2803163510"},"reference-count":57,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2023,8,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p><jats:italic>Moringa oleifera<\/jats:italic> (<jats:italic>M. oleifera<\/jats:italic>) leaves are rich in nutrients and bioactive ingredients. This study was aimed at evaluating the anti\u2010fatigue effect of the ethanol extract of <jats:italic>M. oleifera<\/jats:italic> leaves (MLEE) on mice and its primary mechanism of action using a weight\u2010loaded forced swimming test. In the present study, MLEE was prepared by ultrasound\u2010assisted extraction, and its anti\u2010fatigue effect and antioxidant capacity were evaluated in mice. Mice were administrated MLEE (320\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup> body weight) for 15\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>MLEE supplementation significantly increased levels of glucose and non\u2010esterified fatty acids (NEFA), while decreasing levels of lactate and blood urea nitrogen in serum (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05); the levels of glycogen in the liver and muscle were also increased, as was the activity of glycogen synthase and the level of NEFA in muscle (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). According to a Western blot analysis, MLEE increased the expression of AMPK\u03b11, JNK, AKT and STAT3 in the muscle of mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Our findings indicate that MLEE has an anti\u2010fatigue effect via the AMPK\u2010linked route, which enables it to control energy metabolism and enhance antioxidant enzyme activity. \u00a9 2023 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.12628","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T02:02:17Z","timestamp":1681696937000},"page":"5500-5510","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Anti\u2010fatigue properties of the ethanol extract of <scp><i>Moringa oleifera<\/i><\/scp> leaves in mice"],"prefix":"10.1002","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4423-5085","authenticated-orcid":false,"given":"Xiangyu","family":"Bian","sequence":"first","affiliation":[{"name":"Tianjin Institute of Environmental and Operational Medicine  Tianjin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Wang","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Environmental and Operational Medicine  Tianjin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renren","family":"Yang","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Environmental and Operational Medicine  Tianjin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Ma","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Environmental and Operational Medicine  Tianjin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyun","family":"Dong","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Environmental and Operational Medicine  Tianjin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjiang","family":"Guo","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Environmental and Operational Medicine  Tianjin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weina","family":"Gao","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Environmental and Operational Medicine  Tianjin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-13-218"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2008.03.004"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-198401060-00004"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.02.069"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/594393"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1139\/h2012-064"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867324666170414164607"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2017.12.079"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2019.08.021"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjtm.2017.07.002"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani11020248"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2020.128659"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12072050"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.03.144"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10040532"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.523962"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.5897\/AJB10.1599"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2015.01.002"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2017.06.032"},{"key":"e_1_2_10_21_1","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/3517824","article-title":"Antioxidant and antifatigue properties of the aqueous extract of Moringa oleifera in rats subjected to forced swimming endurance test","volume":"2016","author":"Lamou B, Taiwe GS, Hamadou A, Abene, Houlray J, Atour MM","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chnaes.2021.02.010"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.5344\/ajev.1965.16.3.144"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1996.0292"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22010005"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.08.203"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12970-017-0171-1"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.11609"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.53098"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10030298"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuy001"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-021-01475-0"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2010.12.013"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2010.06.007"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phcgj.2013.03.005"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.32.468"},{"key":"e_1_2_10_37_1","first-page":"32","article-title":"Effect of Trichopus zeylanicus leaf extract on the energy metabolism in mice during exercise and at rest","volume":"34","author":"Evans D","year":"2002","journal-title":"Indian J Pharmacol"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00810.2009"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1965"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.04.045"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.08.053"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705557"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13197-020-04737-3"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12970-021-00449-x"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8070441"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2017-0063"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2019.04.061"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104409"},{"key":"e_1_2_10_49_1","first-page":"20","article-title":"Moringin from Moringa Oleifera seeds inhibits growth, arrests cell\u2010cycle, and induces apoptosis of SH\u2010SY5Y human neuroblastoma cells through the modulation of NF\u2010\u03baB and apoptotic related factors","volume":"2019","author":"Cirmi S","year":"1930","journal-title":"Int J Mol Sci"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2016.108"},{"key":"e_1_2_10_51_1","first-page":"2565","article-title":"Antioxidant effects of the orientin and vitexin in Trollius chinensis Bunge in D\u2010galactose\u2010aged mice","volume":"7","author":"An F","year":"2012","journal-title":"Neural Regen Res"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2013.37.1.1"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm788"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00044.2005"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.892299"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04081-0"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.8220"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31824e0d5d"}],"container-title":["Journal of the Science of Food and Agriculture"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jsfa.12628","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:37:17Z","timestamp":1760877437000},"score":1,"resource":{"primary":{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/10.1002\/jsfa.12628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,28]]},"references-count":57,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,8,30]]}},"alternative-id":["10.1002\/jsfa.12628"],"URL":"https:\/\/doi.org\/10.1002\/jsfa.12628","archive":["Portico"],"relation":{},"ISSN":["0022-5142","1097-0010"],"issn-type":[{"value":"0022-5142","type":"print"},{"value":"1097-0010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,28]]},"assertion":[{"value":"2022-12-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}