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This study is aimed to investigate the mechanism of oat \u03b2\u2010glucan on alleviating muscle atrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The results showed that oat \u03b2\u2010glucan treatment reversed tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) induced abnormal myoblast differentiation and reduced muscle atrophy related MuRF\u20101 and Atrogin\u20101 protein expression. The similar phenomenon was observed after using MCC950 (NLRP3 specific inhibitor) or AS1842856 (FoxO1 specific inhibitor) to suppress NLRP3 and FoxO1 expression, respectively. Exposure to \u03b2\u2010glucan or AS1842856 also inhibited TNF\u2010\u03b1 induced the activation of TLR4\/NF\u2010\u03baB pathway by inactivating FoxO1, and subsequently suppressed the expression of NLRP3.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Our results indicate that oat \u03b2\u2010glucan exerts essential roles in promoting myoblast differentiation and alleviating muscle atrophy via inactivating FoxO1 and NLRP3 inflammasome signal pathway. \u00a9 2023 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.12696","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T19:19:42Z","timestamp":1683746382000},"page":"6252-6262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Oat \u03b2\u2010glucan alleviates muscle atrophy via promoting myotube formation and suppressing protein 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