{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:37:41Z","timestamp":1787506661607,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100015601","name":"Collaborative Innovationcenter of Food Safety and Quality Control in Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2024,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Acne vulgaris is an inflammatory disease of the pilosebaceous unit of the skin that has serious adverse effects on the physical and mental health of patients. Probiotics are extensively employed in dermatology and could be an alternative option for acne therapy. Here, we evaluated the effect of oral ingestion of live and inactivated\n                      <jats:italic>Lactobacillus plantarum<\/jats:italic>\n                      CCFM8661 on oleic acid\u2010induced acne using a mouse model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Results indicated that live\n                      <jats:italic>L. plantarum<\/jats:italic>\n                      CCFM8661 suppressed skin inflammation and serum hormone (insulin and testosterone) production in acne mice. Parallelly, live\n                      <jats:italic>L. plantarum<\/jats:italic>\n                      CCFM8661 effectively reduced the formation of skin lipids (triglycerides and non\u2010esterified free fatty acids), and normalized the expression of skin lipid metabolism\u2010related genes (PPAR\u2010\n                      <jats:italic>\u03b3<\/jats:italic>\n                      , SREBP\u20101c, ACC\n                      <jats:italic>\u03b1<\/jats:italic>\n                      , FASN, PPAR\u2010\n                      <jats:italic>\u03b1<\/jats:italic>\n                      , ACOX1, HSL and ATGL). In comparison, inactivated\n                      <jats:italic>L. plantarum<\/jats:italic>\n                      CCFM8661 had no effect on skin inflammation or serum hormone secretion, but decreased skin triglycerides and normalized the expression of skin lipid metabolism\u2010related genes (PPAR\u2010\n                      <jats:italic>\u03b3<\/jats:italic>\n                      , SREBP\u20101c, FASN and ATGL) in acne mice. Both live and inactivated\n                      <jats:italic>L. plantarum<\/jats:italic>\n                      CCFM8661 raised the richness of gut microbiota, reduced the ratio of Bacteroidetes to Firmicutes and decreased the relative abundance of\n                      <jats:italic>Staphylococcus<\/jats:italic>\n                      in the feces of acne mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      Oral ingestion of\n                      <jats:italic>L. plantarum<\/jats:italic>\n                      CCFM8661, particularly live cells, could alleviate acne by suppressing skin inflammation, normalizing the metabolism of hormones and skin lipids, which may be achieved by improving the gut microbial ecosystem. \u00a9 2023 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.12921","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T02:01:27Z","timestamp":1691978487000},"page":"328-339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Ameliorative effect of\n                    <i>Lactobacillus plantarum<\/i>\n                    <scp>CCFM8661<\/scp>\n                    on oleic acid\u2010induced acne: integrated gut microbiota link to acne pathogenesis"],"prefix":"10.1002","volume":"104","author":[{"given":"Jian","family":"Ai","sequence":"first","affiliation":[{"name":"State Key Laboratory of Food Science and Resources Jiangnan University  Wuxi China"},{"name":"School of Food Science and Technology Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Pharmacy Heilongjiang University of Chinese Medicine  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghao","family":"Pan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Resources Jiangnan University  Wuxi China"},{"name":"School of Food Science and Technology Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6342-1254","authenticated-orcid":false,"given":"Bingyong","family":"Mao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Resources Jiangnan University  Wuxi China"},{"name":"School of Food Science and Technology Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Resources Jiangnan University  Wuxi China"},{"name":"School of Food Science and Technology Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuxiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Resources Jiangnan University  Wuxi China"},{"name":"School of Food Science and Technology Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Resources Jiangnan University  Wuxi China"},{"name":"School of Food Science and Technology Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Resources Jiangnan University  Wuxi China"},{"name":"School of Food Science and Technology Jiangnan University  Wuxi China"},{"name":"National Engineering Research Center for Functional Food Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7055-0484","authenticated-orcid":false,"given":"Shumao","family":"Cui","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Resources Jiangnan University  Wuxi China"},{"name":"School of Food Science and Technology Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.17633"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60321-8"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2017.11.001"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07459-5"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27113460"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00527-7"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijwd.2015.02.001"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13279"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2012.12026"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2019.718"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3920\/BM2016.0089"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13041368"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3920\/BM2012.0060"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13950"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-020-09654-7"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1757-4749-3-1"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8FO02554A"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.736129"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.700696"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2019.01.007"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12103197"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13031017"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2011.06.984"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abo2787"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.3.1.13900"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/83348"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29846-9"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-021-00569-6"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3256241"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-021-00489-2"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14586"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2968"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S114830"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2011.04981.x"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9071486"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3329\/bsmmuj.v5i1.10980"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1677"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R700015-JLR200"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau8465"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12699"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6867962"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2022.105176"},{"key":"e_1_2_10_44_1","first-page":"671","article-title":"The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics","volume":"18","author":"Salminen S","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13296"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21093303"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166026"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2FO00157H"}],"container-title":["Journal of the Science of Food and Agriculture"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jsfa.12921","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:18:27Z","timestamp":1760872707000},"score":1,"resource":{"primary":{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/10.1002\/jsfa.12921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,4]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1,15]]}},"alternative-id":["10.1002\/jsfa.12921"],"URL":"https:\/\/doi.org\/10.1002\/jsfa.12921","archive":["Portico"],"relation":{},"ISSN":["0022-5142","1097-0010"],"issn-type":[{"value":"0022-5142","type":"print"},{"value":"1097-0010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,4]]},"assertion":[{"value":"2023-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}