{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T10:36:31Z","timestamp":1774694191498,"version":"3.50.1"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2024,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Dietary supplementation with trace elements zinc (Zn), iron (Fe) and manganese (Mn) could promote intestinal development and improve intestinal health. There are, however, few studies examining the possibility that maternal original Zn, Fe and Mn could regulate intestinal development and barrier function in the offspring. This study aimed to investigate how the intestinal growth and barrier function of breeder offspring were affected by collagen peptide\u2010chelated trace elements (PTE; Zn, Fe, Mn).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PTE<\/jats:styled-content> supplementation in the diet of breeder hens increased the concentrations of Zn, Fe and Mn in egg yolk. Maternal <jats:styled-content style=\"fixed-case\">PTE<\/jats:styled-content> supplementation improved morphological parameters of the intestine (villi height, crypt depth and villi height\/crypt depth) and upregulated the <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression level of leucine\u2010rich repeat\u2010containing G protein\u2010coupled receptor 5 (<jats:italic>Lgr5<\/jats:italic>) in the ileum of chick embryo<jats:bold>s.<\/jats:bold> Furthermore, maternal PTE effect improved villi height\/crypt depth of offspring at 1 and 14\u2009days of age, and upregulated <jats:italic>Lgr5<\/jats:italic>, <jats:italic>Claudin\u20103<\/jats:italic> and <jats:italic>E\u2010cadherin<\/jats:italic> mRNA expression in the broiler ileum. Additionally, PTE treatment could enhance the intestinal microbial diversity of offspring. Maternal PTE supplementation increased the relative abundance of Clostridiales at the genus level and decreased the relative abundance of <jats:italic>Enterococcus<\/jats:italic> in newborn offspring. Moreover, maternal PTE supplementation ameliorated the elevated nuclear factor kappa B, toll\u2010like receptor 4 and interleukin 1\u03b2 mRNA expression in the ileum of offspring caused by LPS challenge.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Maternal PTE supplementation could promote intestinal development and enhance the intestinal barrier function of chicken offspring. \u00a9 2023 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.12938","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T22:43:23Z","timestamp":1692830603000},"page":"174-183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Dietary collagen peptide\u2010chelated trace elements supplementation for breeder hens improves the intestinal health of chick offspring"],"prefix":"10.1002","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5657-9600","authenticated-orcid":false,"given":"Yongfa","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology China Agricultural University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simeng","family":"Li","sequence":"additional","affiliation":[{"name":"Aksu Vocational and Technical College  Aksu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenwu","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Nanjing Agricultural University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7076-3017","authenticated-orcid":false,"given":"Hongjian","family":"Dai","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Nanjing Agricultural University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6271-6184","authenticated-orcid":false,"given":"Fangxiong","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Nanjing Agricultural University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zengpeng","family":"Lv","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology China Agricultural University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40104-022-00749-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0FO02871A"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps\/pew293"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9214209"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-023-01490-5"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-021-01200-z"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-023-01569-z"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.110.135657"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2013.02.006"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-020-01361-x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.26489"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.112110"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-018-1513-9"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1751731115001329"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-020-02354-x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-2745"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph11040098"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8050757"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-014-0222-2"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15057"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-020-02284-8"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200004273421716"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.117.156042"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.05.007"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2018.01.010"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e12-02-0097"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20225655"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.06.038"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-3551-x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.9941"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps\/pew490"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.4141\/A01-043"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-010-8824-9"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.aambs.2021.09.001"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2009.01514.x"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17075-x"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41396-021-00937-7"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.788836"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.02.010"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2013.01.006"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/03079457.2020.1796926"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2021.01.008"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9351507"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/asia.202100656"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani11051276"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.594150"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00511"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-019-0201-x"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.02.041"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2019-213357"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1670"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201902396R"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.3.397"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2016.04.007"}],"container-title":["Journal of the Science of Food and Agriculture"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jsfa.12938","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:17:49Z","timestamp":1760872669000},"score":1,"resource":{"primary":{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/10.1002\/jsfa.12938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,12]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1,15]]}},"alternative-id":["10.1002\/jsfa.12938"],"URL":"https:\/\/doi.org\/10.1002\/jsfa.12938","archive":["Portico"],"relation":{},"ISSN":["0022-5142","1097-0010"],"issn-type":[{"value":"0022-5142","type":"print"},{"value":"1097-0010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,12]]},"assertion":[{"value":"2023-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}