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Some studies have suggested that vitamin B12 may have anti\u2010inflammatory effects, but the mechanisms underlying this relationship are not yet fully understood. We investigated the relationship between circulating vitamin B12 and inflammatory markers interleukin (IL)\u20106 and C\u2010reactive protein (CRP). The association of peripheral levels of vitamin B12 with IL\u20106 and CRP was assessed in 136 human samples from a high cardiovascular risk population. To corroborate the results from the human trial, the analysis was replicated in naturally aged mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Individuals with higher serum levels of vitamin B12 showed lower concentrations of IL\u20106 and CRP after adjustment for potential confounders, and an inverse association was also found between serum IL\u20106 and vitamin B12 levels in naturally aged mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Circulating vitamin B12 was inversely associated with IL\u20106 and CRP in humans and with IL\u20106 in mice, suggesting that it may exert an anti\u2010inflammatory effect through modulation of these pro\u2010inflammatory molecules. \u00a9 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley &amp; Sons Ltd on behalf of Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.12976","type":"journal-article","created":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T14:53:25Z","timestamp":1694357605000},"page":"875-882","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Higher circulating vitamin\n                    <scp>B12<\/scp>\n                    is associated with lower levels of inflammatory markers in individuals at high cardiovascular risk and in naturally aged mice"],"prefix":"10.1002","volume":"104","author":[{"given":"In\u00e9s","family":"Dom\u00ednguez\u2010L\u00f3pez","sequence":"first","affiliation":[{"name":"Departament de Nutrici\u00f3, Ci\u00e8ncies de l'Alimentaci\u00f3 i Gastronomia, Facultat de Farmacia Universitat de Barcelon (UB)  Barcelona Spain"},{"name":"Institut de 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