{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:28:25Z","timestamp":1788798505857,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T00:00:00Z","timestamp":1698883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2024,1,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Flavonoids are vital for the development of high\u2010quality grapes and wine, and manganese deficiency decreases grape berry coloration. However, the effects and underlying mechanisms of action of manganese sulfate on grape metabolic profiles have not been adequately researched. In this study, three concentrations of manganese sulfate solutions, 0.5\u2009\u03bcmol\u00b7L<jats:sup>\u22121<\/jats:sup> (low, L), 5\u2009\u03bcmol\u00b7L<jats:sup>\u22121<\/jats:sup> (middle, M \u2013 the standard manganese concentration of Hoagland nutrient solution, control), and 1000\u2009\u03bcmol\u00b7L<jats:sup>\u22121<\/jats:sup> (high, H), were applied to the \u2018Cabernet Sauvignon\u2019 grapevine (<jats:italic>Vitis vinifera<\/jats:italic> L.) to explore the effect on berry composition.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Manganese application improved manganese concentration effectively in grape organs. Furthermore, the concentrations of malvidin 3\u2010<jats:italic>O<\/jats:italic>\u2010(6\u2010<jats:italic>O<\/jats:italic>\u2010acetyl)\u2010glucoside, malvidin 3\u2010<jats:italic>O<\/jats:italic>\u2010glucoside, malvidin\u2010trans\u20103\u2010<jats:italic>O<\/jats:italic>\u2010(6\u2010<jats:italic>O<\/jats:italic>\u2010<jats:italic>p<\/jats:italic>\u2010coumaryl)\u2010glucoside, and peonidin 3\u2010<jats:italic>O<\/jats:italic>\u2010(6\u2010<jats:italic>O<\/jats:italic>\u2010acetyl)\u2010glucoside increased significantly under H treatment. Weighted gene co\u2010expression network analysis (WGCNA) revealed that the structural genes (<jats:italic>VvDFR<\/jats:italic>, <jats:italic>VvUFGT<\/jats:italic>, and <jats:italic>VvOMT<\/jats:italic>) of flavonoid biosynthesis were upregulated under H treatment, and their transcription levels correlated positively with malvidin\u2010 and peonidin\u2010derived anthocyanin concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>This study suggested that manganese application regulates berry transcriptional and flavonoid metabolic profiles, providing a theoretical basis for improving the color of red grapes and wines. \u00a9 2023 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.13015","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T09:08:50Z","timestamp":1696237730000},"page":"1092-1106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Manganese sulfate application promotes berry flavonoid accumulation in <scp><i>Vitis vinifera<\/i><\/scp> cv. \u2018Cabernet Sauvignon\u2019 by regulating flavonoid metabolome and transcriptome profiles"],"prefix":"10.1002","volume":"104","author":[{"given":"Ruihua","family":"Ren","sequence":"first","affiliation":[{"name":"College of Enology Northwest A&amp;F University  Yangling China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huangzhao","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Enology Northwest A&amp;F University  Yangling China"},{"name":"College of Food and Biological Engineering Henan University of Animal 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