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The safety and potential bioactivities of <jats:italic>Scheffersomyces segobiensis<\/jats:italic> DSM 27193, an oleaginous yeast strain, are unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p><jats:italic>Scheffersomyces segobiensis<\/jats:italic> DSM 27193 accumulated large palmitoleic acid (POA) levels (43.4\u2009g\u2009kg<jats:sup>\u22121<\/jats:sup> biomass) according to the results of whole\u2010cell components. We annotated the <jats:italic>Kyoto Encyclopedia of Genes and Genomes<\/jats:italic> (KEGG) analysis, and predicted the categories and host of the pathogen\u2013host interactions (PHI) genes in <jats:italic>S. segobiensis<\/jats:italic> DSM 27193. However, <jats:italic>S. segobiensis<\/jats:italic> DSM 27193 did not exert toxic effects in mice. Administration of <jats:italic>S. segobiensis<\/jats:italic> DSM 27193 led to substantial weight reduction by diminishing food intake in an obesity mouse model. Additionally, it reversed hepatic steatosis and adipose tissue hypertrophy, and improved abnormalities in serum biochemical profiles such as triglyceride, total cholesterol, low\u2010density lipoprotein cholesterol, lipopolysaccharide, tumor necrosis factor\u2010\u03b1, interleukin\u20101\u03b2, and interleukin\u20106.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>This study is the first to illustrate the safety and effects of <jats:italic>S. segobiensis<\/jats:italic> DSM 27193 against obesity and offers a scientific rationale for its application in functional food supplements. \u00a9 2023 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.13100","type":"journal-article","created":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T20:30:12Z","timestamp":1699216212000},"page":"2156-2164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Palmitoleic acid\u2010rich oleaginous yeast <scp><i>Scheffersomyces segobiensis<\/i><\/scp> DSM 27193 exerts anti\u2010obesity effects by ameliorating hepatic steatosis and adipose tissue hypertrophy"],"prefix":"10.1002","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0559-4095","authenticated-orcid":false,"given":"Yujia","family":"Peng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Materials\u2010Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering Nanjing Tech University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Materials\u2010Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering Nanjing Tech University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinhui","family":"Bao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of 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