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Diquat exposure causes growth retardation and intestinal damage. Therefore, this study was performed to investigate the effects of melatonin on diquat\u2010challenged piglets.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Dietary supplementation with 2\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup> melatonin significantly increased the average daily gain and feed conversion rate in piglets. Melatonin increased antioxidant capacity, and improved intestinal epithelial barrier function of duodenum and jejunum in piglets. Moreover, melatonin was found to regulated the expression of immune and antioxidant\u2010related genes. Melatonin also alleviated diquat\u2010induced growth retardation and anorexia in diquat\u2010challenged piglets. It also increased antioxidant capacity, and ameliorated diquat\u2010induced intestinal epithelial barrier injury. Melatonin also regulated the expression of <jats:italic>MnSOD<\/jats:italic> and immuner\u2010elated genes in intestinal.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Dietary supplementation with 2\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup> melatonin increased antioxidant capacity to ameliorate diquat\u2010induced oxidative stress, alleviate intestinal epithelial barrier injury, and increase growth performance in weaned piglets. \u00a9 2023 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.13114","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T09:45:20Z","timestamp":1699609520000},"page":"2262-2271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Melatonin increased antioxidant capacity to ameliorate growth retardation and intestinal epithelial barrier dysfunction in diquat\u2010challenged piglets"],"prefix":"10.1002","volume":"104","author":[{"given":"Andong","family":"Zha","sequence":"first","affiliation":[{"name":"Laboratory of Animal Nutritional Physiology and Metabolic Process, Key Laboratory of Agro\u2010Ecological Processes in Subtropical Region, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture Chinese Academy of Sciences  Changsha China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiameng","family":"Yan","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Nutritional Physiology and Metabolic Process, Key Laboratory of Agro\u2010Ecological Processes in Subtropical Region, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture Chinese Academy of Sciences  Changsha 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