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Carboxylpyranoanthocyanin is one of the simplest pyranoanthocyanin, among which the production of carboxylpyranocyanidin\u20103\u2010<jats:italic>O<\/jats:italic>\u2010glucoside (crboxyl\u2010pycy\u20103\u2010gluc) is most feasible as a result of the abundance of its reactant, cyanidin\u20103\u2010<jats:italic>O<\/jats:italic>\u2010glucoside (Cy\u20103\u2010gluc).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In the present study, carboxyl\u2010pycy\u20103\u2010gluc was synthesized and its stability during processing and after ingestion as well as its bioavailability <jats:italic>in vivo<\/jats:italic> were comprehensively evaluated. Our results indicated that the color of carboxyl\u2010pycy\u20103\u2010gluc remained more stable compared to Cy\u20103\u2010gluc when facing the large\u2010span pH variation. The high retention of anthocyanin symbolized the superb stability under thermal processing, sulfur dioxide bleaching and ultrasonic treatment of carboxyl\u2010pycy\u20103\u2010gluc. Because of the stability under the alkaline condition, carboxyl\u2010pycy\u20103\u2010gluc is more stable after oral\u2010gastrointestinal digestion. After <jats:italic>in vitro<\/jats:italic> gut microbiota fermentation, the retention of carboxyl\u2010pycy\u20103\u2010gluc was significantly higher than that of Cy\u20103\u2010gluc. The larger molecular size made absorption of carboxyl\u2010pycy\u20103\u2010gluc into blood more difficult than its precursor.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The present study demonstrated the promising stability of carboxyl\u2010pycy\u20103\u2010gluc during food processing and after digestion, confirming the potential of carboxyl\u2010pycy\u20103\u2010gluc as a colorant. \u00a9 2023 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.13122","type":"journal-article","created":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T09:18:55Z","timestamp":1699694335000},"page":"2372-2382","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The promising stability of <scp>carboxylpyranocyanidin\u20103\u2010<i>O<\/i><\/scp>\u2010glucoside during food processing and simulated digestion and its bioavailability 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