{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T15:48:30Z","timestamp":1778600910824,"version":"3.51.4"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32102106"],"award-info":[{"award-number":["32102106"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2024,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hyperlipidemia is characterized by abnormally elevated blood lipids. Quinoa saponins (QS) have multiple pharmacological activities, including antitumor, bactericidal and immune\u2010enhancing effects. However, the lipid\u2010lowering effect and mechanisms of QS <jats:italic>in vivo<\/jats:italic> have been scarcely reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The effect of QS against hyperlipidemia induced by high\u2010fat diet in rats was explored based on gut microbiota and serum non\u2010targeted metabolomics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study demonstrated that the supplementation of QS could reduce serum lipids, body weight, liver injury and inflammation. 16S rRNA sequencing demonstrated that QS mildly increased alpha\u2010diversity, altered the overall structure of intestinal flora, decreased the relative richness of Firmicutes, the ratio of Firmicutes\/Bacteroidetes (<jats:italic>P\u2009&lt;<\/jats:italic>\u20090.05) and increased the relative richness of Actinobacteria, Bacteroidetes, <jats:italic>Bifidobacterium<\/jats:italic>, <jats:italic>Roseburia<\/jats:italic> and <jats:italic>Coprococcus<\/jats:italic> (<jats:italic>P\u2009&lt;<\/jats:italic>\u20090.05). Simultaneously, metabolomics analysis showed that QS altered serum functional metabolites with respect to bile acid biosynthesis, arachidonic acid metabolism and taurine and hypotaurine metabolism, which were closely related to bile acid metabolism and fatty acid <jats:italic>\u03b2<\/jats:italic>\u2010oxidation. Furthermore, QS increased protein levels of farnesoid X receptor, peroxisome proliferator\u2010activated receptor <jats:italic>\u03b1<\/jats:italic> and carnitine palmitoyltransferase 1, which were related to the screened metabolic pathways. Spearman correlation analysis showed that there was a correlation between gut microbiota and differential metabolites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>QS could prevent lipid metabolism disorders in hyperlipidemic rats, which may be closely associated with the regulation of the gut microbiota and multiple metabolic pathways. This study may provide new evidence for QS as natural active substances for the prevention of hyperlipidemia. \u00a9 2023 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.13127","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T06:17:03Z","timestamp":1700633823000},"page":"2417-2428","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Saponins from <i>Chenopodium quinoa<\/i> Willd. husks alleviated high\u2010fat\u2010diet\u2010induced hyperlipidemia via modulating the gut microbiota and multiple metabolic pathways"],"prefix":"10.1002","volume":"104","author":[{"given":"Yuan","family":"Yu","sequence":"first","affiliation":[{"name":"Clinical Nutrition Department, First Affiliated Hospital of Weifang Medical University (Weifang People's Hospital)  Weifang People's Republic of China"},{"name":"School of Public Health Weifang Medical University  Weifang 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