{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T14:38:54Z","timestamp":1785335934840,"version":"3.55.0"},"reference-count":60,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T00:00:00Z","timestamp":1704412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2024,3,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p><jats:italic>Parkia biglobosa<\/jats:italic> stem bark extracts were prepared using methanol, methanol 80%, water and ethyl acetate to investigate their phytochemical contents, as well as antioxidant and enzyme inhibitory properties.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Liquid chromatography (LC) quadrupole time\u2010of\u2010flight mass spectrometry (MS) and LC\u2010MS<jats:sup>n<\/jats:sup> revealed the presence of flavonoids, hydroxycinnamic acid derivatives and gallotannins. Particularly, the water extract contained rutin (480\u2009\u03bcg per 100\u2009mg) and 3\u2010caffeoylquinic acid (1109\u2009\u03bcg per 100\u2009mg) in higher amounts, whereas the 80% methanol extract contains methoxyluteolin\u20107\u2010<jats:italic>O<\/jats:italic>\u2010rutinoside and catechin derivatives as major compounds. Total phenolic and flavonoid contents of the extracts were yielded in the range of 32.26\u2013119.88\u2009mg gallic acid equivalents g<jats:sup>\u22121<\/jats:sup> and 0.60\u20132.39\u2009mg rutin equivalents g<jats:sup>\u22121<\/jats:sup>, respectively. Total antioxidant capacity was also displayed in the range of 0.53\u20136.34\u2009mmol Trolox equivalents (TE)\u2009g<jats:sup>\u22121<\/jats:sup>. Both the methanolic extracts showed higher total antioxidant capacity that could be related to the total phenolic contents. Radical scavenging capacity in DPPH (2,2\u2010diphenyl\u20102\u2010picryl\u2010hydrazyl) (37.21\u2013508.30\u2009mg TE\u2009g<jats:sup>\u22121<\/jats:sup>) and ABTS [2,2\u2010azinobis(3\u2010ethylbenzothiazoline\u2010 6\u2010sulfonic acid)] (60.95\u20131068.06\u2009mg TE\u2009g<jats:sup>\u22121<\/jats:sup>) assays, reducing power in cupric ion reducing antioxidant capacity (54.23\u20131002.78\u2009mg TE\u2009g<jats:sup>\u22121<\/jats:sup>) and ferric ion reducing antioxidant power (33.18\u2013558.68\u2009mg TE\u2009g<jats:sup>\u22121<\/jats:sup>) assays, as well as metal chelating activity (2.45\u201311.28\u2009mg EDTA equivalents g<jats:sup>\u22121<\/jats:sup>), were exhibited by all extracts. All extracts were found to inhibit acetylcholinesterase [0.23\u20132.47\u2009mg galanthamine equivalents (GALAE)\u2009g<jats:sup>\u22121<\/jats:sup>], tyrosinase [27.20\u201383.33\u2009mg kojic acid equivalents\u2009g<jats:sup>\u22121<\/jats:sup>], amylase [mmol acarbose equivalents (ACAE)\u2009g<jats:sup>\u22121<\/jats:sup>]. On the other hand, all extracts, except the water extract, inhibited butyrylcholinesterase (5.38\u20136.56\u2009mg GALAE\u2009g<jats:sup>\u22121<\/jats:sup>), whereas only the water and ethyl acetate extract showed glucosidase inhibitory potential (1.96 and 1.82\u2009mmol ACAE\u2009g<jats:sup>\u22121<\/jats:sup>). In general, the water extract was found to be a weaker enzyme inhibitor suggesting that water is not the preferrable extraction solvent to obtain active products.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The present study demonstrated that the stem bark extracts of <jats:italic>P. biglobosa<\/jats:italic> contains good amount of phytochemical and extracts present significant antioxidant, as well as reasonable enzyme inhibitory effects. Hence, these findings suggest that further studies can be performed on more specific biological targets and models of bioactivity to determine their safe usage as a nutraceutical or for the preparation functional foods. \u00a9 2023 The Authors. <jats:italic>Journal of The Science of Food and Agriculture<\/jats:italic> published by John Wiley &amp; Sons Ltd on behalf of Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.13170","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T17:57:37Z","timestamp":1701107857000},"page":"2820-2831","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Bioactive agents from <i>Parkia biglobosa<\/i> (Jacq.) R.Br. ex G. Don bark extracts for health promotion and nutraceutical uses"],"prefix":"10.1002","volume":"104","author":[{"given":"Stefania","family":"Sut","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical and Pharmacological Sciences University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8264-6953","authenticated-orcid":false,"given":"Stefano","family":"Dall'Acqua","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Pharmacological Sciences University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouadio Ibrahime","family":"Sinan","sequence":"additional","affiliation":[{"name":"Department of Biology, Science Faculty Selcuk University  Konya 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