{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T11:09:48Z","timestamp":1776424188294,"version":"3.51.2"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T00:00:00Z","timestamp":1703721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31800676"],"award-info":[{"award-number":["31800676"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32001772"],"award-info":[{"award-number":["32001772"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2024,3,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Rosmarinic acid (RA) is an active polyphenol that is widely found in various edible herbs. This study explored the potential anti\u2010allergic activities and the underlying mechanisms of RA in ovalbumin (OVA)\u2010induced intestinal allergic mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Forty female BALB\/c mice were randomly divided into five groups: control group, model group (OVA sensitized\/challenged), RA\u2010Low group (OVA sensitized\/challenged, 30\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup> RA intervention), RA\u2010Middle group (OVA sensitized\/challenged, 90\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup> RA intervention) and RA\u2010High group (OVA sensitized\/challenged, 270\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup> RA intervention). RA effectively attenuated allergic reactions, including alleviating allergic symptoms and regulating the hypothermia of mice in the model group. Moreover, the anaphylactic mediator (OVA\u2010specific IgE, histamine and mMCP\u20101) levels of OVA allergic mice were markedly decreased after RA intervention. Quantitative polymerase chain reaction analysis showed that RA significantly inhibited Th2 cytokine expression, while Th1 and Treg cytokines were markedly increased. 16S rRNA gene sequence analysis indicated that RA effectively regulated the richness and diversity of the intestinal microbiota in OVA allergic mice. At the phylum level, the relative abundance of Bacteroidetes and Firmicutes and the Firmicutes\/Bacteroidetes ratio were altered by RA intervention. At the genus level, RA was found to regulate the disturbances in the relative abundance of <jats:italic>Muribaculaceae<\/jats:italic>, <jats:italic>Lactobacillus<\/jats:italic> and <jats:italic>Prevotella<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>RA exhibited potential anti\u2010allergic activity in OVA allergic mice by regulating hypersensitive immune responses and the intestinal microbiota structure. These results provide important evidence that RA can be developed into a novel functional food\u2010derived ingredient against food allergy. \u00a9 2023 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.13192","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T02:58:35Z","timestamp":1701831515000},"page":"3002-3012","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Effects of rosmarinic acid on immune response and intestinal microbiota in ovalbumin\u2010induced intestinal allergy mice"],"prefix":"10.1002","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0241-7649","authenticated-orcid":false,"given":"Qing","family":"Yang","sequence":"first","affiliation":[{"name":"Key Laboratory for Deep Processing of Major Grain and Oil, Ministry of Education Wuhan Polytechnic University  Wuhan China"},{"name":"Food Safety Research Center Key Research Institute of Humanities and Social of Hubei Province  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binmei","family":"Jia","sequence":"additional","affiliation":[{"name":"Key Laboratory for Deep Processing of Major Grain and Oil, Ministry of Education Wuhan Polytechnic University  Wuhan China"},{"name":"Food Safety Research Center Key Research Institute of Humanities and Social of Hubei Province  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieli","family":"Shang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Deep Processing of Major Grain and Oil, Ministry of Education Wuhan Polytechnic University  Wuhan China"},{"name":"Food Safety Research Center Key Research Institute of Humanities and Social of Hubei Province  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuanpei","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Deep Processing of Major Grain and Oil, Ministry of Education Wuhan Polytechnic University  Wuhan China"},{"name":"Food Safety Research Center Key Research Institute of Humanities and Social of Hubei Province  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Deep Processing of Major Grain and Oil, Ministry of Education Wuhan Polytechnic University  Wuhan China"},{"name":"Food Safety Research Center Key Research Institute of Humanities and Social of Hubei Province  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Deep Processing of Major Grain and Oil, Ministry of Education Wuhan Polytechnic University  Wuhan China"},{"name":"Food Safety Research Center Key Research Institute of Humanities and Social of Hubei Province  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Fang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Deep Processing of Major Grain and Oil, Ministry of Education Wuhan Polytechnic University  Wuhan China"},{"name":"Food Safety Research Center Key Research Institute of Humanities and Social of Hubei Province  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengbo","family":"Zeng","sequence":"additional","affiliation":[{"name":"Wuhan BioCSi Tech Laboratory Co. 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