{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:01:03Z","timestamp":1782482463922,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Qizha Shuangye granules (QSG) comprise six traditional Chinese herbal medicines (TCHMs), which have a long history of treating hyperlipidemia (HLP) in China. This study aimed to evaluate the potential lipid\u2010lowering effects of QSG in an HLP rat model and investigate possible mechanisms. The HLP rat model was induced by a high\u2010fat diet. Lipid\u2010related indicators in serum were detected. Serum and liver metabolites were investigated using a liquid chromatography\u2013mass spectrometry\u2010based metabolomics approach. A herb\u2013compound\u2013target\u2013metabolite (H\u2010C\u2010T\u2010M) network was further constructed to reveal the possible molecular mechanism of QSG to alleviate HLP.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The administration of QSG inhibited the HLP\u2010induced changes in total cholesterol, triglyceride, low\u2010density lipoprotein cholesterol, high\u2010density lipoprotein cholesterol, and non\u2010esterified fatty acid (NEFA) levels. Additionally, QSG significantly attenuated the liver histopathological changes induced by HLP. Metabolomic analysis showed the serum and liver metabolic disorders presented in HLP rats. QSG can reverse the abnormal metabolism caused by HLP. Through network pharmacology analysis, key proteins such as androgen receptor, 3\u2010hydroxy\u20103\u2010methylglutaryl\u2010CoA reductase, and peroxisome proliferator\u2010activated receptor\u2010\u03b1 were screened out, and they were speculated to be possible therapeutic targets for QSG to treat HLP.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The present study integrated metabolomics and network pharmacology analysis to reveal the efficacy and possible mechanism of QSG in treating HLP, which provides a new reference for the research and development of QSG as a functional food. \u00a9 2023 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.13213","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T23:35:50Z","timestamp":1702424150000},"page":"3265-3274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Integrated 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