{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:28:32Z","timestamp":1787736512332,"version":"build-2784847793"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100015598","name":"Institution of South China Sea Ecology and Environmental Engineering, Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015598","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Our preliminary research revealed that the polysaccharide GP90 from <jats:italic>Gracilariopsis lemaneiformis<\/jats:italic> enhanced the antitumor effect of cisplatin, indicating that GP90 may increase the chemotherapeutic sensitivity. However, it is still necessary to fully understand whether GP90 can also improve the intestinal barrier dysfunction and systemic inflammation induced by cisplatin.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>GP90 has been demonstrated to inhibit the excessive release of nitirc oxide, interleukin (IL)\u20106, IL\u20101\u03b2 and tumor necrosis factor (TNF)\u2010\u03b1 induced by lipopolysaccharide in RAW264.7 cells. <jats:italic>In vivo<\/jats:italic>, GP90 effectively ameliorated the decrease in the serum CD4<jats:sup>+<\/jats:sup>\/CD8<jats:sup>+<\/jats:sup> T\u2010cell ratio induced by cisplatin and significantly reduced the increase in the inflammatory cytokines, CD4<jats:sup>+<\/jats:sup>Foxp3<jats:sup>+<\/jats:sup>, CD4<jats:sup>+<\/jats:sup>granzyme B<jats:sup>+<\/jats:sup> and CD4<jats:sup>+<\/jats:sup>TNF\u2010\u03b1 induced by cisplatin. Furthermore, when combined with cisplatin, GP90 increases the protein expression levels of mucin\u20102 and zonula occludens\u20101 in the mouse small intestine. Additionally, GP90 combined with cisplatin has a modulatory effect on the intestinal microbiota by elevating the Firmicutes\u2010to\u2010Bacteroidetes ratio and the relative abundance of beneficial microorganisms (<jats:italic>Lachnospiraceae bacterium<\/jats:italic>), at the same time as reducing the abundance of cisplatin specific <jats:italic>Bacteroides acidifaciens<\/jats:italic> and elevating the content of butyric acid and isobutyric acid.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Collectively, these findings indicate that GP90 potentially mitigates inflammation and protects the intestinal barrier in tumor\u2010bearing organisms undergoing chemotherapy. \u00a9 2024 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.13260","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T01:25:07Z","timestamp":1705541107000},"page":"3757-3766","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Administration of <i>Gracilariopsis lemaneiformis<\/i> polysaccharide attenuates cisplatin\u2010induced inflammation and intestinal mucosal damage in colon\u201026 carcinoma tumor\u2010bearing mice"],"prefix":"10.1002","volume":"104","author":[{"given":"Bingna","family":"Cai","sequence":"first","affiliation":[{"name":"Key Laboratory of Tropical Marine Bio\u2010resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica South China Sea Institute of Oceanology, Chinese Academy of Sciences  Guangzhou China"},{"name":"Innovation Academy of South China Sea Ecology and Environmental Engineering (ISEE) Chinese Academy of Sciences  Guangzhou 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