{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T03:51:34Z","timestamp":1789271494115,"version":"build-2803163510"},"reference-count":77,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Crataegus orientalis<\/jats:italic>\n                      Pall. ex M. Bieb fruit (COPMB) is extensively used as a source of various products in the medicinal\u2010aromatic field and holds the potential for erosion control, ornamental purposes, food source, and economic benefits for forest villagers from its fruits. This study aims to determine the chemical components and biological activities of extracts prepared from COPMB using different solvents.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The present work was designed to define the antioxidant activity [phosphomolybdenum (total antioxidant capacity), 2,2\u2032\u2010azino\u2010bis(3\u2010ethylbenzothiazoline\u20106\u2010sulfonic acid) (ABTS), ferric reducing antioxidant power (FRAP), cupric ion\u2010reducing antioxidant capacity (CUPRAC) and metal chelating activity (MCA)], phytochemical screening analysis, enzyme inhibitor (\u03b1\u2010amylase, \u03b1\u2010glucosidase and tyrosinase) potential, and liquid chromatography\u2010high resolution mass spectrometry (LC\u2010HRMS) secondary metabolite profiling in different extracts of COPMB. The results of LC\u2010HRMS revealed that fumaric acid was the main phenolic compound in all extracts. Among the extracts, ethyl acetate extract has the highest phytochemical and antioxidant properties [total phenolic content (TPC): 32.5\u2009mg GAE\/g, total flavonoid content (TFC): 12.2\u2009mg QE\/g, ABTS: 213.0\u2009mg TE\/g; CUPRAC: 126.0\u2009mg TE\/g, MCA: 145.0\u2009mg EDTA\/g; FRAP: 122.8\u2009mg TE\/g; TAC: 2.8\u2009mmol TE\/g]. Ethyl acetate and methanol extracts are more effective in \u03b1\u2010amylase (0.27\u2009\u00b1\u20090.01\u2009mg\/mL; 0.12\u2009\u00b1\u20090.00\u2009mg\/mL), \u03b1\u2010glucosidase (0.63\u2009\u00b1\u20090.02\u2009mg\/mL; 0.77\u2009\u00b1\u20090.02\u2009mg\/mL) and tyrosinase (0.03\u2009\u00b1\u20090.00\u2009mg\/mL; 0.03\u2009\u00b1\u20090.00\u2009mg\/mL) enzyme inhibition potentials compared to standard acarbose (0.75\u2009\u00b1\u20090.02\u2009mg\/mL for \u03b1\u2010amylase; 1.11\u2009\u00b1\u20090.03\u2009mg\/mL for \u03b1\u2010glucosidase) and kojic acid (0.04\u2009\u00b1\u20090.00\u2009mg\/mL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>The findings from this study suggest that COPMB could serve as a valuable source of natural agents for the food and pharmaceutical industry. \u00a9 2024 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.13261","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T07:40:04Z","timestamp":1706514004000},"page":"3767-3775","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Phytochemical analyses by\n                    <scp>LC\u2010HRMS<\/scp>\n                    ,\n                    <scp>FTIR<\/scp>\n                    spectral analysis, antioxidant, antidiabetic and antityrosinase activity of\n                    <i>Crataegus orientalis<\/i>\n                    Pall. ex M. Bieb fruit extracted with various solvents"],"prefix":"10.1002","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8719-2436","authenticated-orcid":false,"given":"Ummuhan","family":"Cakmak","sequence":"first","affiliation":[{"name":"Faculty of Science, Department of Chemistry Karadeniz Technical University  Trabzon Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2020.11.011"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2020.07.013"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/87559129.2016.1225220"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/138955712798868995"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202300265"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bse.2021.104225"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2019.111693"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2018.11.014"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.5772\/66844"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8NJ00347E"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodcont.2015.07.003"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiosc.2021.02.003"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03033137"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2021.122012"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2023.05.030"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v6.i4.598"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hermed.2018.09.001"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.07.073"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2017.05.014"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2022.05.045"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2009.04.010"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2017.1286358"},{"key":"e_1_2_10_24_1","first-page":"1","article-title":"Extractions of aerial parts of Hippomarathrum scabrum with conventional and green methodologies: chemical profiling, antioxidant, enzyme inhibition, and anti\u2010cancer effects","volume":"2300678","author":"Nilofar DT","year":"2023","journal-title":"J Sep Sci"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10722-010-9633-x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8339.2005.00392.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8339.2007.00682.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2019.04.012"},{"key":"e_1_2_10_29_1","first-page":"120","article-title":"Mu\u011fla\u2010Fethiye Y\u00f6resinde Do\u011fal Yay\u0131l\u0131\u015f Yapan Al\u0131\u00e7 (Crataegus Orientalis Pall. 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