{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T19:12:34Z","timestamp":1788894754591,"version":"build-2803163510"},"reference-count":70,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      The objective of this study is to investigate the antiproliferative, antioxidant, antimicrobial, and enzyme activity capacities and phytochemical compositions of\n                      <jats:italic>Thymus pectinatus<\/jats:italic>\n                      (TP),\n                      <jats:italic>Thymus convolutus<\/jats:italic>\n                      (TC), which are endemic to T\u00fcrkiye. Quantitative analysis of phenolic compounds in the extracts was conducted using liquid chromatography\u2013tandem mass spectrometry, targeting 53 phenolic compounds.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Rosmarinic acid, quinic acid, and cynaroside were identified as the major compounds, exhibiting quantitative variation in both extracts. The extracts had a high total phenolic content, with 113.57\u2009\u00b1\u20090.58\u2009mg gallic acid equivalents (GAE)\/g extract for TP and 130.52\u2009\u00b1\u20091.05\u2009mg GAE\/g extract for TC. Furthermore, although both extracts exhibited high total flavonoid content; the TP extract (75.12\u2009\u00b1\u20091.65\u2009mg quercitin equivalents (QE)\/g extract) displayed a higher flavonoid content than the TC extract (30.24\u2009\u00b1\u20090.74\u2009mg QE\/g extract) did. The extracts had a promising antiproliferative effect on C6, HeLa, and HT29 cancer cell lines with a less cytotoxic effect (10.5\u201314.2%) against normal cells. Both extracts exhibited very potent inhibitory activity against the xanthine oxidase enzyme, with half\u2010maximal inhibitory concentration values of respectively 2.07\u2009\u00b1\u20090.03\u2009\u03bcg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      and 2.76\u2009\u00b1\u20090.06\u2009\u03bcg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      and moderate activity against tyrosinase and\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2010glucosidase. Docking simulations proved that rosmarinic acid and cynaroside, the major components of the extracts, were the most potent inhibitors of xanthine oxidase. According to antimicrobial activity results, the TC extract exhibited moderate activity against\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      , and the TP extract had strong activity against both\n                      <jats:italic>Enterococcus faecium<\/jats:italic>\n                      and\n                      <jats:italic>S. aureus<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      These findings emphasize the beneficial effects of the two endemic\n                      <jats:italic>Thymus<\/jats:italic>\n                      species on human health and suggest their potential use as plant\u2010derived bioactive agents. \u00a9 2024 Society of Chemical Industry.\n                    <\/jats:p>\n                  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