{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:16:26Z","timestamp":1790025386619,"version":"4.0.1"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T00:00:00Z","timestamp":1705968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Selenium is an important nutritional supplement that mainly exists naturally in soil as inorganic selenium. <jats:italic>Saccharomyces cerevisiae<\/jats:italic> cells are excellent medium for converting inorganic selenium in nature into organic selenium.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Under the co\u2010stimulation of sodium selenite (Na<jats:sub>2<\/jats:sub>SeO<jats:sub>3<\/jats:sub>) and potassium selenite (K<jats:sub>2<\/jats:sub>SeO<jats:sub>3<\/jats:sub>), the activity of selenophosphate synthetase (SPS) was improved up to about five folds more than conventional Na<jats:sub>2<\/jats:sub>SeO<jats:sub>3<\/jats:sub> group with the total selenite salts content of 30\u2009mg\/L. Transcriptome analysis first revealed that due to the sharing pathway between sodium ion (Na<jats:sup>+<\/jats:sup>) and potassium ion (K<jats:sup>+<\/jats:sup>), the K<jats:sup>+<\/jats:sup> largely regulates the metabolisms of amino acid and glutathione under the accumulation of selenite salt. Furthermore, K<jats:sup>+<\/jats:sup> could improve the tolerance performance and selenium\u2010biotransformation yields of <jats:italic>Saccharomyces cerevisiae<\/jats:italic> cells under Na<jats:sub>2<\/jats:sub>SeO<jats:sub>3<\/jats:sub> salt stimulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The important role of K<jats:sup>+<\/jats:sup> in regulating the intracellular selenium accumulation especially in terms of amino acid metabolism and glutathione, suggested a new direction for the development of selenium\u2010enrichment supplements with <jats:italic>Saccharomyces cerevisiae<\/jats:italic> cell factory. \u00a9 2024 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.13295","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T07:53:50Z","timestamp":1705996430000},"page":"4136-4144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Co\u2010metabolism of Na<sup>+<\/sup>\/K<sup>+<\/sup> ion regulated physiological enhancement on selenium\u2010accumulation in <scp><i>Saccharomyces<\/i><\/scp> yeasts"],"prefix":"10.1002","volume":"104","author":[{"given":"Wenhui","family":"Hao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, School of Food Science and Technology Jiangnan University  Wuxi P. 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