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Probiotics influence both iron metabolism and inflammation. We compared the inflammatory state in rats on a HF iron\u2010deficient diet receiving oral iron, <jats:italic>Lactobacillus plantarum<\/jats:italic> and <jats:italic>Lactobacillus curvatus<\/jats:italic> in different combinations.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>This was a two\u2010stage experiment. In groups C (<jats:italic>n<\/jats:italic>\u2009=\u20098) and HF (<jats:italic>n<\/jats:italic>\u2009=\u20098), rats ate a control or HF diet, respectively, for 16\u2009weeks. In the group HFDEF (<jats:italic>n<\/jats:italic>\u2009=\u200948), rats ate a HF iron\u2010deficient diet for 8\u2009weeks (first stage) and were subsequently divided into 6 groups (<jats:italic>n<\/jats:italic>\u2009=\u20098 each) receiving the following for a further 8\u2009weeks (second stage): HFDEF \u2013 a HF iron\u2010deficient diet; HFDEFFe \u2013 a HF iron\u2010deficient diet with iron; HFDEFLp and HFDEFLc \u2013 a HF iron\u2010deficient diet with <jats:italic>L. plantarum<\/jats:italic> or <jats:italic>L. curvatus<\/jats:italic>, respectively; and HFDEFFeLp and HFDEFFeLc \u2013 a HF iron\u2010deficient diet with iron and <jats:italic>L. plantarum<\/jats:italic> or <jats:italic>L. curvatus<\/jats:italic>, respectively. Body composition analysis and blood sampling was performed. Markers of iron status and levels of total antioxidant status (TAS), C\u2010reactive protein (CRP), tumour necrosis factor alpha (TNF\u2010<jats:italic>\u03b1<\/jats:italic>) and interleukin 6 (IL\u20106) were measured in the blood.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>TAS was higher in the HFDEF group (756.57\u2009\u00b1\u2009489.53\u2009ng\u2009mL<jats:sup>\u22121<\/jats:sup>) <jats:italic>versus<\/jats:italic> the HFDEFLc group (187.04\u2009\u00b1\u200947.84\u2009ng\u2009mL<jats:sup>\u22121<\/jats:sup>; <jats:italic>P<\/jats:italic>\u2009=\u20090.022). No more differences were found between groups, or in TAS, CRP, TNF\u2010<jats:italic>\u03b1<\/jats:italic> and IL\u20106 concentrations. Also, no differences were found between groups for alanine and aspartate aminotransferases, glucose, total cholesterol, low\u2010 and high\u2010density lipoproteins and triglycerides. TAS level was positively correlated with ferritin concentration, IL\u20106 with TAS and TNF\u2010<jats:italic>\u03b1<\/jats:italic> with hepcidin level.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Supplementation with <jats:italic>L. plantarum<\/jats:italic>, <jats:italic>L. curvatus<\/jats:italic> and iron in combinations exerts no influence on inflammatory status, lipid profile, hepatic function and serum fasting glucose in rats on a HF iron\u2010deficient diet. \u00a9 2024 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.13329","type":"journal-article","created":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T02:53:41Z","timestamp":1707533621000},"page":"4411-4424","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Influence of supplementation with iron and probiotic bacteria <scp><i>Lactobacillus plantarum<\/i><\/scp> and <scp><i>Lactobacillus curvatus<\/i><\/scp> on selected parameters of inflammatory state in rats on a high\u2010fat iron\u2010deficient diet"],"prefix":"10.1002","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4173-5965","authenticated-orcid":false,"given":"Katarzyna","family":"Skrypnik","sequence":"first","affiliation":[{"name":"Institute of Human Nutrition and Dietetics, Poznan University of Life Sciences  Poznan Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8417-2245","authenticated-orcid":false,"given":"Marcin","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Food Biotechnology and Microbiology Poznan University of Life Sciences  Poznan Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5418-5632","authenticated-orcid":false,"given":"Agnieszka","family":"Olejnik\u2010Schmidt","sequence":"additional","affiliation":[{"name":"Department of Food 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