{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T19:34:42Z","timestamp":1782156882690,"version":"3.54.5"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:00:00Z","timestamp":1709856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32302229"],"award-info":[{"award-number":["32302229"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2024,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Food allergy has become a global public health problem. This study aimed to explore the possible anti\u2010allergic effect of vitamin C (VC). A rat basophilic leukemia (RBL)\u20102H3 cell degranulation model was used to assess the effect of VC on degranulation <jats:italic>in vitro<\/jats:italic>, and an ovalbumin (OVA)\u2010induced BALB\/c mouse allergy model was used to assess the anti\u2010allergy effect of VC <jats:italic>in vivo<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p><jats:italic>In vitro<\/jats:italic>, VC significantly attenuated the release of \u03b2\u2010hexosaminidase, tryptase and histamine, and also reduced cytokine production (interleukins 4 and 6, tumor necrosis factor \u03b1) significantly (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), with the inhibitory effect demonstrating a positive correlation with VC dose. <jats:italic>In vivo<\/jats:italic>, compared with the OVA group, the levels of serum immunoglobulins E and G<jats:sub>1<\/jats:sub> of the VC low\u2010dose (VCL) group (50\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>) and high\u2010dose (VCH) group (200\u2009mg\u00b7kg<jats:sup>\u22121<\/jats:sup>) were significantly reduced (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Furthermore, the plasma histamine level was also significantly decreased (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Moreover, T<jats:sub>H<\/jats:sub>2 cell polarization in mice of the VCL and VCH groups was significantly inhibited (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), promoting the T<jats:sub>H<\/jats:sub>1\/T<jats:sub>H<\/jats:sub>2 cell polarization balance. Additionally, VC treatment enhanced the expression of CD80 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) in spleen and small intestine tissues, while significantly inhibiting the expression of CD86 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05); notably, high\u2010dose VC treatment was more effective.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>VC exerted an anti\u2010allergic effect through inhibiting degranulation and regulating T<jats:sub>H<\/jats:sub>1\/T<jats:sub>H<\/jats:sub>2 cell polarization balance. \u00a9 2024 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.13419","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T07:49:37Z","timestamp":1709106577000},"page":"5955-5963","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Anti\u2010allergic effect of vitamin C through inhibiting degranulation and regulating 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