{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T01:35:21Z","timestamp":1789781721601,"version":"4.0.1"},"reference-count":47,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Maslinic acid (MA), a pentacyclic triterpene acid, is widely distributed in natural plants and mainly found in the fruit and leaves of olives and hawthorn. MA has been reported as having many health\u2010promoting functions, such as anticancer, anti\u2010inflammation and neuroprotective activities. According to previous study, hawthorn extract has certain hepatoprotective effects. However, the detailed mechanism is still unclear, especially the effect of MA on gut microbiota.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Our study reveals that MA effectively counteracts alcohol\u2010induced liver injury and oxidative stress. It mitigates alcohol\u2010induced intestinal barrier damage, reverses increased permeability and reduces translocation of lipopolysaccharide (LPS). This prevents LPS\/Toll\u2010like receptor 4 activation, leading to decreased TNF\u2010<jats:italic>\u03b1<\/jats:italic> and IL\u20101<jats:italic>\u03b2<\/jats:italic> production. Furthermore, MA rebalances gut microbiota by reversing harmful bacterial abundance and enhancing beneficial bacteria post\u2010alcohol consumption.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>MA, through modulation of gut microbiota, alleviates alcohol\u2010induced liver injury via the gut\u2013liver axis. These findings support the potential use of MA as a functional food ingredient for preventing or treating alcoholic liver disease. \u00a9 2024 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.13624","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T09:35:38Z","timestamp":1717580138000},"page":"7928-7938","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Maslinic acid alleviates alcoholic liver injury in mice and regulates intestinal microbiota via the gut\u2013liver axis"],"prefix":"10.1002","volume":"104","author":[{"given":"Jingwen","family":"Su","sequence":"first","affiliation":[{"name":"Jiangsu Co\u2010Innovation Center of Efficient Processing and Utilization of Forest Resources Nanjing Forestry University  Nanjing China"},{"name":"College of Chemical Engineering Nanjing Forestry University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Dai","sequence":"additional","affiliation":[{"name":"Jiangsu Yanghe Distillery Co. 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