{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:40:40Z","timestamp":1788910840893,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32072145"],"award-info":[{"award-number":["32072145"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Lack of n\u20103 polyunsaturated fatty acids during the period of maternity drastically lowers the docosahexaenoic acid (DHA) level in the brain of offspring and studies have demonstrated that different molecular forms of DHA are beneficial to brain development. The aim of this study was to investigate the effect of short\u2010term supplementation with DHA\u2010enriched phosphatidylserine (PS) and phosphatidylcholine (PC) on DHA levels in the liver and brain of congenital n\u20103\u2010deficient mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Dietary supplementation with DHA significantly changed the fatty acid composition of various phospholipid molecules in the cerebral cortex and liver while DHA\u2010enriched phospholipid was more effective than DHA triglyceride (TG) in increasing brain and liver DHA. Both DHA\u2010PS and DHA\u2010PC could effectively increase the DHA levels, but DHA in the PS form was superior to PC in the contribution of DHA content in the brain ether\u2010linked PC (ePC) and liver lyso\u2010phosphatidylcholine molecular species. DHA\u2010PC showed more significant effects on the increase of DHA in liver TG, PC, ePC, phosphatidylethanolamine (PE) and PE plasmalogen (pPE) molecular species and decreasing the arachidonic acid level in liver PC plasmalogen, ePC, PE and pPE molecular species compared with DHA\u2010PS.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The effect of dietary interventions with different molecular forms of DHA for brain and liver lipid profiles is different, which may provide theoretical guidance for dietary supplementation of DHA for people. \u00a9 2024 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.13625","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T15:54:16Z","timestamp":1717689256000},"page":"7939-7952","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effects of short\u2010term supplementation with <scp>DHA<\/scp>\u2010enriched phosphatidylcholine and phosphatidylserine on lipid profiles in the brain and liver of n\u20103 <scp>PUFA<\/scp>\u2010deficient mice in early life after weaning"],"prefix":"10.1002","volume":"104","author":[{"given":"Wei\u2010Ya","family":"Zuo","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering Ocean University of China  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wen","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Ocean University of China  Qingdao China"},{"name":"Institute of Biopharmaceutical Research Liaocheng University  Liaocheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Cai","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Ocean University of China  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Yue","family":"Li","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Ocean University of China  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Hu","family":"Xue","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Ocean University of China  Qingdao China"},{"name":"Laboratory of Marine Drugs &amp; Biological Products Pilot National Laboratory for Marine Science and Technology (Qingdao)  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruyoshi","family":"Yanagita","sequence":"additional","affiliation":[{"name":"Laboratory of Nutrition Biochemistry, Department of Applied Biochemistry and Food Science Saga University  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2310-1456","authenticated-orcid":false,"given":"Yu\u2010Ming","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Ocean University of China  Qingdao China"},{"name":"Laboratory of Marine Drugs &amp; Biological Products Pilot National Laboratory for Marine Science and Technology (Qingdao)  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5162-0408","authenticated-orcid":false,"given":"Tian\u2010Tian","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Ocean University of China  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12123615"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13041185"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22136965"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2016.05.014"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2016.07.011"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0FO02552F"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-12-178"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.14017"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2018.04.017"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2018.05.009"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201801224"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-020-01253-3"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.42.47"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)64849-5"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.5650\/jos.ess20212"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2010.11.001"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028451"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1FO03345J"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2016.03.005"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuaa060"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/10942912.2022.2070642"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c06462"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2014.10.014"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2014.06.002"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23094635"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164326"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2019.01.022"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2019.100997"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.706523"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2012.05.008"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.12788"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00185a019"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.946393"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2018.tb00008.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.017"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.730829"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11050299"}],"container-title":["Journal of the Science of Food and Agriculture"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jsfa.13625","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:02:59Z","timestamp":1760871779000},"score":1,"resource":{"primary":{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/10.1002\/jsfa.13625"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,6]]},"references-count":37,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/jsfa.13625"],"URL":"https:\/\/doi.org\/10.1002\/jsfa.13625","archive":["Portico"],"relation":{},"ISSN":["0022-5142","1097-0010"],"issn-type":[{"value":"0022-5142","type":"print"},{"value":"1097-0010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,6]]},"assertion":[{"value":"2023-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}