{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:48:38Z","timestamp":1787500118712,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>This study aimed to elucidate the mechanism of oleuropein (OLE) ameliorates non\u2010alcoholic fatty liver disease (NAFLD) and its underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Male C57BL\/6J mice were fed either a low\u2010fat diet (LFD), a high\u2010fat diet (HFD), or a HFD supplemented with 0.03% (\n                      <jats:italic>w\/w<\/jats:italic>\n                      ) OLE for 16\u2009weeks. OLE supplementation decreased body weight and liver weight, improved serum lipid profiles, and ameliorated HFD\u2010induced hepatic dysfunction. Liver metabolomics analysis revealed that OLE increased the levels of nicotinamide, tauroursodeoxycholic acid, taurine, and docosahexaenoic acid, which were beneficial for lipid homeostasis and inflammation regulation. OLE exerted its protective effects by activating peroxisome proliferator\u2010activated receptor alpha (PPAR\u03b1), a key transcription factor that regulates fibroblast growth factor 21 (FGF21) expression and modulates lipid oxidation, lipogenesis and inflammation pathways. Importantly, OLE supplementation did not significantly affect body weight or liver weight in PPAR\u03b1 knockout (PPAR\u03b1 KO) mice, indicating that PPAR\u03b1 is essential for OLE\u2010mediated NAFLD prevention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Our results suggest that OLE alleviates NAFLD in mice by activating PPAR\u03b1 and modulating liver metabolites. \u00a9 2024 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.13691","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T03:48:57Z","timestamp":1719892137000},"page":"8634-8645","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Oleuropein mitigates non\u2010alcoholic fatty liver disease (NAFLD) and modulates liver metabolites in high\u2010fat diet\u2010induced obese mice via activating\n                    <scp>PPAR\u03b1<\/scp>"],"prefix":"10.1002","volume":"104","author":[{"given":"Wei","family":"Zhou","sequence":"first","affiliation":[{"name":"Center for Prevention and Treatment of Cardiovascular Diseases The Second Affiliated Hospital of Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Du","sequence":"additional","affiliation":[{"name":"The First People's Hospital of Lianyungang Public Health Department  Lianyungang 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