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It is known that terpenoids in quinoa have anti\u2010inflammatory and antitumor effects, but their role in reversing drug resistance remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Our previous studies showed that quinoa\u2010derived terpenoid compounds (QBT) can inhibit the occurrence and development of colon cancer. This study further indicates that QBT markedly reverse drug resistance of colon cancer. The results showed that QBT combined with 5\u2010fluorouracil (5\u2010Fu) treatment significantly enhanced the chemotherapy sensitivity of HCT\u20108\/Fu, compared with 5\u2010Fu treatment alone. Moreover, we found that QBT significantly reduced the expression of drug\u2010resistant proteins (P\u2010gp, MRP1, BCRP), and increased the accumulation of chemotherapy drugs. Taking P\u2010gp as the target for biogenesis prediction analysis, results showed that upregulation of miR\u2010495\u20103p enhanced the chemosensitivity of drug\u2010resistant HCT\u20108\/Fu cells. Besides, the results showed that miR\u2010495\u20103p was abnormally methylated in HCT\u20108\/Fu compared with HCT\u20108 colon cancer cells. The expression of methyltransferases DNMT1, DNMT3a and DNMT3b was abnormal. After QBT treatment, the expression level of methyltransferases returned to normal. In addition, the QBT\u2009+\u20095Fu group showed inhibition of tumors in nude mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>QBT treatment downregulated the expression of drug\u2010resistant protein P\u2010gp by inhibiting the methylation of miR\u2010495\u20103p, and enhanced the accumulation of 5\u2010Fu <jats:italic>in vivo<\/jats:italic>, which in turn reversed its chemoresistance. This suggests that QBT has potential ability as a new drug\u2010resistance reversal agent in colorectal cancer. \u00a9 2024 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.13718","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T05:49:21Z","timestamp":1720072161000},"page":"8916-8927","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Terpenoids from quinoa reverse drug resistance of colon cancer by upregulating <scp>miR<\/scp>\u2010495\u20103p"],"prefix":"10.1002","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7222-5113","authenticated-orcid":false,"given":"Mangmang","family":"Feng","sequence":"first","affiliation":[{"name":"Institute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Shanxi University  Taiyuan 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