{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:38:01Z","timestamp":1792460281060,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>The supplemental effect of zinc depends not only on adequate intake, but also on how efficiently it is absorbed in the small intestine. In the present study, weak hydrophobic peptides (WHP), strong hydrophobic peptides (SHP), positively charged peptides (PCP) and negatively charged peptides (NCP) were isolated from soybean peptides (SP). The peptide\u2010Zn complexes (PCP\u2010Zn, NCP\u2010Zn, WHP\u2010Zn, SHP\u2010Zn and SP\u2010Zn) were prepared to compare their promotion zinc absorption capacity in the Caco\u20102 cells monolayers model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      We found that the carboxyl, carbonyl and amino groups in peptide were the primary binding sites of Zn. Compared with zinc sulfate, the peptide\u2010Zn complexes with different charge and hydrophobic peptides could improve zinc solubility at different pH. NCP\u2010Zn had a lower Zn\u2010binding capacity but a higher zinc absorption capacity compared to that of PCP\u2010Zn in Caco\u20102 cells. In addition, the capacity of PCP\u2010Zn to promote zinc absorption was lower than the control group (SP\u2010Zn). There were no significant differences in transport rates, retention rates and uptake rates of WHP\u2010Zn, SHP\u2010Zn and SP\u2010Zn. NCP\u2010Zn could improve the activity of Zn\u2010related enzymes, and the expression levels of\n                      <jats:italic>PepT1<\/jats:italic>\n                      and\n                      <jats:italic>ZnT1<\/jats:italic>\n                      were higher than other peptide\u2010Zn complexes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>The promotion zinc absorption capacity of peptide\u2010Zn complexes was not completely dependent on the Zn\u2010binding capacity, but also depended on the charge and hydrophobicity of peptides. \u00a9 2024 Society of Chemical Industry.<\/jats:p>\n                  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