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The purpose of this study is to separate peanut ferrous\u2010chelating peptides and explore the chelation mechanism of peanut peptides with iron.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Peanut peptide component F\u2010122, which had a higher chelation rate, was separated using ultrafiltration, gel filtration chromatography, and ion exchange chromatography, achieving a ferrous chelation rate of 90.7%. Six peptide segments were screened and their amino acid sequences were identified by liquid chromatography\u2013tandem mass spectrometry (LC\u2013MS\/MS). Spectral analysis confirmed that the chelation between peanut peptides and ferrous ions occurred and a new substance was formed. Molecular docking simulation indicated that the amino acids in peanut peptides involved in the chelating reaction were glutamic acid, arginine, glycine, threonine, phenylalanine, and lysine. The binding sites included the main chain oxygen atom, side chain oxygen atom, and carboxyl oxygen atom of amino acid.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The isolated peanut peptide had a higher ferrous\u2010chelation rate. The chelating mechanism of peanut peptide with ferrous ion was elucidated. This study provides a theoretical basis for the development of new peptide\u2010ferrous preparations. \u00a9 2024 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.13759","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T23:07:27Z","timestamp":1722035247000},"page":"9368-9378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Isolation, identification, and chelation mechanism of ferrous\u2010chelating peptide from peanut protein hydrolysate"],"prefix":"10.1002","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5867-986X","authenticated-orcid":false,"given":"Guanhao","family":"Bu","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering Henan University of Technology  Zhengzhou 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