{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T04:18:53Z","timestamp":1773116333656,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p><jats:italic>Lactocaseibacillus paracasei<\/jats:italic> subsp. <jats:italic>paracasei<\/jats:italic> NTU 101 (NTU101) is a well\u2010known commercial probiotic with multiple health beneficial effects. In this study, the gut microbiota modulation effect of an NTU 101 product, Vigiis 101\u2010LAB, on healthy human was investigated in a randomized, double\u2010blind, placebo\u2010controlled human trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Vigiis 101\u2010LAB significantly modulated human gut microbiota at fourth and sixth weeks of trial (anosim analysis, <jats:italic>P<\/jats:italic>\u2009=\u20090.001). It also significantly improved peristalsis (<jats:italic>P<\/jats:italic>\u2009=\u20090.003) and shortened defecation interval of subjects. The shift of gut microbiota is significantly fit with defecation interval (<jats:italic>P<\/jats:italic>\u2009=\u20090.009) and stool shape (<jats:italic>P<\/jats:italic>\u2009=\u20090.001) of subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Our results suggest that Vigiis 101\u2010LAB promotes human intestinal health with improvement of peristalsis and fecal quality. The gut modulation effects of Vigiis 101\u2010LAB subsequently raised the abundance of vitamin B7, vitamin K, pyrimidine and purine biosynthesis pathways. Vigiis 101\u2010LAB may promote peristalsis via purinergic pathway and possibly conferring prophylactic benefits against irritable bowel syndrome with constipation. \u00a9 2024 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.13772","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T08:38:31Z","timestamp":1721896711000},"page":"9494-9505","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of <scp><i>Lactocaseibacillus paracasei<\/i><\/scp> subsp. <scp><i>paracasei<\/i> NTU<\/scp> 101 on gut microbiota: a randomized, double\u2010blind, placebo\u2010controlled clinical study"],"prefix":"10.1002","volume":"104","author":[{"given":"Tzu\u2010Hsing","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Life Science National Taitung University  Taitung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsung\u2010Wei","family":"Shih","sequence":"additional","affiliation":[{"name":"SunWay Biotech Ltd.  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