{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:36:35Z","timestamp":1791549395158,"version":"4.3.4"},"reference-count":52,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T00:00:00Z","timestamp":1722556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The widespread use of quercetin is limited by its instability, low solubility and poor oral bioavailability. Encapsulation of quercetin using a nanoparticle delivery system is an effective way to overcome these drawbacks.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The effect of the molecular weight (<jats:italic>M<\/jats:italic><jats:sub>w<\/jats:sub>) of chitosan (CS) (100, 200, 500 and 1000\u2009kDa) on quercetin\u2010loaded chitosan nanoparticles (QCNPs) was investigated. The structure, stability, release properties and antioxidant activities of the nanoparticles (QCNP\u201010, QCNP\u201020, QCNP\u201050 and QCNP\u2010100) were assessed. Particle size of QCNPs decreased and polydispersity index increased with the increasing <jats:italic>M<\/jats:italic><jats:sub>w<\/jats:sub> of CS. The main forces involved in the formation of QCNPs were hydrogen bonding and hydrophobic interaction. X\u2010ray diffraction verified that quercetin was loaded into CS nanoparticles. The photostability and thermal stability of QCNPs increased with increasing <jats:italic>M<\/jats:italic><jats:sub>w<\/jats:sub> of CS. QCNP\u2010100 exhibited the lowest release rate in a mixture of water and anhydrous ethanol. The antioxidant activities of QCNPs were enhanced with increasing <jats:italic>M<\/jats:italic><jats:sub>w<\/jats:sub> of CS, and QCNP\u2010100 possessed the highest antioxidant activities, which might be relevant to its smallest particle size.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Overall, these results revealed that the <jats:italic>M<\/jats:italic><jats:sub>w<\/jats:sub> of CS affected the properties of QCNPs, and QCNP\u2010100 possessed the smallest particle, best stability, lowest release rate and highest antioxidant activities. \u00a9 2024 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.13777","type":"journal-article","created":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T01:54:22Z","timestamp":1722650062000},"page":"9531-9539","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effect of molecular weight of chitosan on quercetin\u2010loaded 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