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Probiotics and goat milk have garnered widespread attention for their ability to modulate immune function and regulate the endocrine system, and for their anti\u2010inflammatory effects. In this work, the effects of Tibetan goat kefir on the behavior, immune status, neuroendocrine response and gut microbiological composition of chronic unpredictable mild stress (CUMS) mouse models were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The results indicated that Tibetan kefir goat milk significantly alleviated behavioral despair in mice. Furthermore, the results demonstrated that Tibetan kefir goat milk mitigated the inflammatory response in the mice and moderated the hyperactivity of the hypothalamic\u2013pituitary\u2013adrenal axis and the expression of brain\u2010derived neurotrophic factor. Meanwhile, chronic stress\u2010induced gut microbial abnormalities were restored. In addition, the correlation between gut microbiota and nervous system was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>These results explained the potential mechanism of Tibetan kefir in the antidepressant effect on the CUMS model and enriched diets for depressed patients. \u00a9 2024 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.13825","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T08:46:12Z","timestamp":1724402772000},"page":"266-275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prophylactic effects of <scp>Tibetan<\/scp> goat kefir on depression\u2010like behaviors in chronic unpredictable stress model through the gut\u2013brain axis"],"prefix":"10.1002","volume":"105","author":[{"given":"Yuhan","family":"Sun","sequence":"first","affiliation":[{"name":"College of Food Science and Technology Northwest 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