{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T01:20:17Z","timestamp":1789435217448,"version":"build-2803163510"},"reference-count":65,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2025,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Deer oil (DO), a byproduct of deer meat processing, possesses high nutritional value. This study aims to evaluate the protective effects of DO on dextran sulfate sodium (DSS)\u2010induced ulcerative colitis (UC) in mice and to explore its potential mechanisms of action.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>DO was found to inhibit weight loss and colon shortening in colitis mice, significantly reduce disease activity index scores, and notably enhance the levels of tight junction proteins in colon tissues, thus improving intestinal barrier function. ELISA results indicated that DO markedly alleviated the mice's oxidative stress and inflammatory responses. Western blot analysis further demonstrated that DO significantly inhibited the phosphorylation of NF\u2010\u03baB while up\u2010regulating the expression levels of Nrf2 and HO\u20101 proteins. Additionally, DO increased the abundance of beneficial bacteria such as <jats:italic>Odoribacter<\/jats:italic>, <jats:italic>Blautia<\/jats:italic>, and <jats:italic>Muribaculum<\/jats:italic>, reduced the abundance of harmful bacteria such as <jats:italic>Bacteroides<\/jats:italic>, <jats:italic>Helicobacter<\/jats:italic>, and <jats:italic>Escherichia\u2010Shigella<\/jats:italic>, and promoted the production of short\u2010chain fatty acids.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Our study provides the first evidence that DO can effectively improve DSS\u2010induced UC in mice. The underlying mechanisms may involve maintaining intestinal barrier function, inhibiting inflammation, alleviating oxidative stress, and modulation of gut microbiota. These findings offer valuable insights for developing DO as an adjunct treatment for UC and as a functional food. \u00a9 2024 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.13837","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T06:41:40Z","timestamp":1724740900000},"page":"382-393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Deer oil improves ulcerative colitis induced by <scp>DSS<\/scp> in mice by regulating the intestinal microbiota and <scp>SCFAs<\/scp> metabolism and modulating <scp>NF<\/scp>\u2010<scp>\u03baB<\/scp> and <scp>Nrf2<\/scp> signaling pathways"],"prefix":"10.1002","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6438-4292","authenticated-orcid":false,"given":"Hongyan","family":"Li","sequence":"first","affiliation":[{"name":"College of Traditional Chinese Medicine Jilin Agricultural University  Changchun 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