{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:44:46Z","timestamp":1790358286897,"version":"4.1.0"},"reference-count":78,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD2100200"],"award-info":[{"award-number":["2023YFD2100200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32302148"],"award-info":[{"award-number":["32302148"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2025,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Fecal microbiota transplantation (FMT) of healthy donors improves ulcerative colitis (UC) patients by restoring the balance of the gut microbiota. However, donors vary in microbial diversity and composition, often resulting in weak or even ineffective FMT. Improving the efficacy of FMT through combination treatment has become a promising strategy.\n                      <jats:italic>Ulva lactuca<\/jats:italic>\n                      polysaccharides (ULP) have been found to benefit host health by regulating gut microbiota. The effect of the combination of ULP and FMT in ameliorating UC has not yet been evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The present study found that supplementation with ULP combined with FMT showed better effects in ameliorating UC than supplementation with FMT alone. Results suggested that FMT or ULP combined with FMT alleviated the symptoms of UC in mice, as evidenced by prevention of body weight loss, improvement of disease activity index and protection of the intestinal mucus. Notably, ULP in combination with FMT was more effective than FMT in reducing levels of cytokines and related inflammatory enzymes. In addition, ULP combined with FMT effectively restored the dysbiosis induced by dextran sulfate sodium (DSS) and further enriched probiotics (such as\n                      <jats:italic>Bifidobacterium<\/jats:italic>\n                      ). The production of short\u2010chain fatty acids, especially acetic acid, was also significantly enriched by ULP combined with FMT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Supplementation of ULP combined with FMT could significantly ameliorate DSS\u2010induced colitis in mice by inhibiting inflammation and restoring dysbiosis of gut microbiota. These results suggested that ULP combined with FMT has potential application in ameliorating UC. \u00a9 2024 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.13839","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T05:47:34Z","timestamp":1724996854000},"page":"422-432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<i>Ulva lactuca<\/i>\n                    polysaccharides combined with fecal microbiota transplantation ameliorated dextran sodium sulfate\u2010induced colitis in\n                    <scp>C57BL<\/scp>\n                    \/\n                    <scp>6J<\/scp>\n                    mice"],"prefix":"10.1002","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1067-0496","authenticated-orcid":false,"given":"Zhengqi","family":"Liu","sequence":"first","affiliation":[{"name":"Shenzhen Key Laboratory of Food Nutrition and Health College of Chemistry and Environmental Engineering, Institute for Innovative Development of Food Industry, Shenzhen University  Shenzhen PR China"},{"name":"National Engineering Research Center of Seafood, National and Local Joint Engineering Laboratory for Marine Bioactive Polysaccharide Development and Application School of Food Science and Technology, Dalian Polytechnic University  Dalian PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menghui","family":"Wang","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Food Nutrition and Health College of Chemistry and Environmental Engineering, Institute for Innovative Development of Food Industry, Shenzhen University  Shenzhen PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Hu","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Food Nutrition and Health College of Chemistry and Environmental Engineering, Institute for Innovative Development of Food Industry, Shenzhen University  Shenzhen PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjin","family":"Li","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Food Nutrition and Health College of Chemistry and Environmental Engineering, Institute for Innovative Development of Food Industry, Shenzhen University  Shenzhen PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Gong","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Food Nutrition and Health College of Chemistry and Environmental Engineering, Institute for Innovative Development of Food Industry, Shenzhen University  Shenzhen PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Guo","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Food Nutrition and Health College of Chemistry and Environmental Engineering, Institute for Innovative Development of Food Industry, Shenzhen University  Shenzhen PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9718-8254","authenticated-orcid":false,"given":"Shuang","family":"Song","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Seafood, National and Local Joint Engineering Laboratory for Marine Bioactive Polysaccharide Development and Application School of Food Science and Technology, Dalian Polytechnic University  Dalian PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beiwei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Food Nutrition and Health College of Chemistry and Environmental Engineering, Institute for Innovative Development of Food Industry, Shenzhen University  Shenzhen PR China"},{"name":"National Engineering Research Center of Seafood, National and Local Joint Engineering Laboratory for Marine Bioactive Polysaccharide Development and Application School of Food Science and Technology, Dalian Polytechnic University  Dalian PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.11.026"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32448-0"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.150"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9248589"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000001246"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06005"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1237-9"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.02.009"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01592.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2020.1847976"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10071371"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izad091"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11091674"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13914"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12365"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-023-08958-0"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12910-017-0200-2"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-014-0454-4"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i21.2834"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.09.061"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-018-0541-8"},{"key":"e_1_2_10_23_1","first-page":"2650","article-title":"Fecal microbiota transplantation ameliorates active ulcerative colitis","volume":"19","author":"Chen HT","year":"2020","journal-title":"Exp Ther Med"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-319407"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6923609"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-022-03766-z"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.120806"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.001"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.08.098"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.03.053"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0FO01162B"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0258-z"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2019.103641"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.15319"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2015.05.031"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.115852"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.algal.2021.102477"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/life13041026"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/md18100499"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.05.109"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2022.135287"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1998.00357.x"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00580-010-0979-4"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/jobm.201500726"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2005.10.008"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.4028\/www.scientific.net\/AMR.340.416"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.06.116"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2FO02712G"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14232"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/md21050298"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2023.01.013"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.f.303"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2021.110562"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.04.107"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2FO02964B"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-016-4060-2"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjaa050"},{"key":"e_1_2_10_58_1","article-title":"Investigating intestinal inflammation in DSS\u2010induced model of IBD","volume":"60","author":"Kim JJ","year":"2012","journal-title":"J Vis Exp"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.04.020"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.05.033"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20753"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/24.3.353"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9FO02165E"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-013-0270-5"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.0c04773"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.08.006"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.12.003"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.953962"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22158070"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2009.06.006"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2020.1826746"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17207618"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.1998.tb01654.x"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2236-y"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12041107"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MIB.0000435444.14860.ea"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01434"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1FO01200B"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.756299"}],"container-title":["Journal of the Science of Food and Agriculture"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jsfa.13839","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:55:24Z","timestamp":1760867724000},"score":1,"resource":{"primary":{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/10.1002\/jsfa.13839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,30]]},"references-count":78,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1,15]]}},"alternative-id":["10.1002\/jsfa.13839"],"URL":"https:\/\/doi.org\/10.1002\/jsfa.13839","archive":["Portico"],"relation":{},"ISSN":["0022-5142","1097-0010"],"issn-type":[{"value":"0022-5142","type":"print"},{"value":"1097-0010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,30]]},"assertion":[{"value":"2024-03-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}