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In this study, DSS was used to induce a liver injury from a colitis model in piglets, which was expected to prevent and alleviate DSS\u2010induced liver injury by feeding sodium isobutyrate in advance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results showed that sodium isobutyrate could restore DSS\u2010induced histopathological changes in the liver, inhibit the activation of the toll\u2010like receptor\u20094\/myeloid differentiation primary response\u200988\/nuclear factor kappa\u2010B signaling pathway, and then reduce the DSS\u2010induced release of pro\u2010inflammatory cytokines tumor necrosis factor\u2010<jats:italic>\u03b1<\/jats:italic>, interleukin\u20091<jats:italic>\u03b2<\/jats:italic>, and interleukin\u20096, reducing inflammatory response. Moreover, we found that sodium isobutyrate could play an antioxidant and apoptosis\u2010reducing role by maintaining reduced mitochondrial function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, sodium isobutyrate has a preventive and protective effect on liver injury in a DSS\u2010induced colitis. There is a potential application prospect for it in treating ulcerative\u2010colitis\u2010induced liver injuries. \u00a9 2024 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.14021","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T06:33:41Z","timestamp":1731566021000},"page":"2486-2496","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Isobutyrate exerts a protective effect against liver injury in a DSS\u2010induced colitis by inhibiting inflammation and oxidative stress"],"prefix":"10.1002","volume":"105","author":[{"given":"Haiyang","family":"Liu","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology Northeast Agricultural University  Harbin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqing","family":"Du","sequence":"additional","affiliation":[{"name":"College of Animal 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