{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:32:07Z","timestamp":1790371927087,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2025,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lead (Pb) is a metal that affects many body systems, primarily the male reproductive system. This study aimed to examine the phytochemical profiling and beneficial effects of <jats:italic>Juglans regia<\/jats:italic> oil (JRO) in alleviating lead\u2010induced reprotoxicity\u2010associated oxidative injury in rats. Adult male Wistar rats were randomly divided into four groups as follows: control group received no treatment, Pb group was exposed to 0.344\u2009g\u2009kg<jats:sup>\u22121<\/jats:sup> bw of Pb acetate, Pb\u2009+\u2009JRO group was co\u2010treated with Pb plus walnut oil (0.9\u2009g\u2009kg<jats:sup>\u22121<\/jats:sup> bw) and JRO group received walnut oil only.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pb\u2010treated rats showed significantly decreased gonado\u2010somatic index, count and viability of sperm. Testosterone levels decreased in Pb\u2010treated animals. Besides, Pb disrupted the oxidative\/antioxidative status, the plasmatic lipase activity and testicular Pb content. Furthermore, Pb produced testis histopathological features, especially cell degeneration, atrophy and tubular disarrangement. Co\u2010treatment with JRO was found to be effective for recovering the increased testicular oxidative damage\u2010associated histological features in the Pb group. This was supported by the <jats:italic>in silico<\/jats:italic> modeling results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The <jats:italic>in silico<\/jats:italic> analyses revealed that JRO compounds bound androgen receptor and RAC\u2010alpha serine\/threonine kinase with high affinities, which together with pharmacokinetic properties and molecular interactions satisfactorily support the beneficial <jats:italic>in vivo<\/jats:italic> findings in the Pb\u2009+\u2009JRO group of rats. \u00a9 2024 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.14024","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T22:34:14Z","timestamp":1731623654000},"page":"2515-2526","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Protective effects of <scp><i>Juglans regia<\/i><\/scp> oil on lead acetate\u2010induced reprotoxicity in rats: an 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