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This study conducted a systematic review across four databases to examine the potential effects of dietary fibers on dental caries. Data selection and extraction were conducted independently and in duplicate. From 962 found titles, twenty studies were included, of which 13 were <jats:italic>in vitro<\/jats:italic>. The substances identified as prebiotics included fructo\u2010oligosaccharides (FOS), galacto\u2010oligosaccharides (GOS), inulin, pectin, raffinose, polydextrose, sialyllactose, and short\u2010chain fatty acids. Outcomes were assessed at biofilm (n\u2009=\u200914), saliva (n\u2009=\u20095), and tooth (n\u2009=\u20091) levels, with only six studies\u00a0evaluating pH changes. Fifteen studies (75%) reported potential benefits, primarily attributed to the capacity of prebiotic fibers to limit the growth or adhesion of bacteria. Only two studies (10%) reported an increase in pH. Overall, the quality of the evidence was judged as moderate. 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