{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:20:55Z","timestamp":1787239255839,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hainan Province","doi-asserted-by":"publisher","award":["KF202207"],"award-info":[{"award-number":["KF202207"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.32260562"],"award-info":[{"award-number":["No.32260562"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Prenylated flavonoids are widely distributed in plants, including fruits and vegetables in the Moraceae and Fabaceae families. These chemicals are potential functional food ingredients owing to their attractive biological activities. However, natural prenylated flavonoids are rare, which limits their application.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Here, we reported the prenylation of apigenin and genistein catalyzed by DMATS1, a dimethylallyl\u2010\n                      <jats:sc>l<\/jats:sc>\n                      \u2010tryptophan synthase from\n                      <jats:italic>Fusarium fujikuroi<\/jats:italic>\n                      . High\u2010performance liquid chromatography\u2013tandem mass spectrometry and nuclear magnetic resonance identified their structure as 6\u2010\n                      <jats:italic>C<\/jats:italic>\n                      \u2010prenylapigenin (6\u2010PA) and 6\u2010\n                      <jats:italic>C<\/jats:italic>\n                      \u2010prenylgenistein (6\u2010PG), respectively. Cell\u2010based assay suggested that both 6\u2010PA and 6\u2010PG induced the proliferation of THP\u20101 cells under low concentrations and were safe in doses less than 50\u2009\u03bcmol\u2009L\n                      <jats:sup>\u22121<\/jats:sup>\n                      . 6\u2010PA and 6\u2010PG exhibited significant anti\u2010inflammatory activity in lipopolysaccharide\u2010stimulated THP\u20101 cells, and inhibited the production of nitric oxide as well as downregulating the transcriptional levels of pro\u2010inflammatory cytokines, including tumor necrosis factor\u2010\u03b1, interleukin\u20108, and interleukin\u20101\u03b2.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      The findings suggested that DMATS1 could catalyze the 6\u2010\n                      <jats:italic>C<\/jats:italic>\n                      prenylation of apigenin and genistein, and the generated 6\u2010PA and 6\u2010PG exhibited anti\u2010inflammatory activity, aiding in the recognition of 6\u2010PA and 6\u2010PG as nutraceuticals. \u00a9 2025 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.14198","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T23:43:26Z","timestamp":1741736606000},"page":"4586-4597","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prenylation of flavonoids by\n                    <scp>DMATS1<\/scp>\n                    and their anti\u2010inflammatory activities"],"prefix":"10.1002","volume":"105","author":[{"given":"Zhengjiao","family":"Gao","sequence":"first","affiliation":[{"name":"School of Food Science and Engineering, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Collaborative Innovation Center of Nanfan and 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