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However, research on the simultaneous analysis of inorganic and organic species in complex matrices remains limited. This study presents a rapid and sensitive method for the concurrent determination of arsenic and selenium species using reversed\u2010phase chromatography with inductively coupled plasma\u2010mass spectrometry. Enzyme\u2010assisted extraction was employed to enhance the efficiency of target analyte recovery.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>By utilizing ion\u2010pairing reagents and a mobile phase consisting of 20\u2009mmol\u2009L<jats:sup>\u22121<\/jats:sup> citric acid with 2.0% methanol at pH\u20094.0, six arsenic species and five selenium species were simultaneously analyzed in kinetic energy discrimination mode within 10\u2009min. The limits of detection for arsenic and selenium species ranged from 0.058 to 0.6\u2009\u03bcg\u2009kg<jats:sup>\u22121<\/jats:sup> and 0.083 to 0.283\u2009\u03bcg\u2009kg<jats:sup>\u22121<\/jats:sup>, respectively. The precision\u00a0of the spiked American ginseng samples ranged from 1.07% to 11.08%, with recovery rates between 72.13% and 107.2%. The method successfully identified and quantified 11 elemental species.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The analysis of real American ginseng samples revealed that the predominant arsenic species were inorganic arsenic(V), while the primary selenium species was organic selenomethionine. This study provides a valuable and efficient method for the simultaneous monitoring of elemental species in functional foods, contributing to their safety assessment and quality control. \u00a9 2025 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.14211","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T02:08:02Z","timestamp":1741745282000},"page":"4822-4832","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ion\u2010pairing reversed\u2010phase chromatography with inductively coupled plasma\u2010mass spectrometry applied to simultaneous determination of arsenic and selenium species in functional food American ginseng"],"prefix":"10.1002","volume":"105","author":[{"given":"Jianjie","family":"Wu","sequence":"first","affiliation":[{"name":"Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing P. 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