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This study aimed to thoroughly investigate the effect of prebiotics on parameters indicative of allergic asthma induced by ovalbumin (OVA), house dust mites (HDM) and OVA + lipopolysaccharide (LPS). The review was registered in the Open Science Framework (registration ID: osf.io\/du4ab). PRISMA and web\u2010app Rayyan were used as tools for the selection of studies collected in seven databases: PubMed; ScienceDirect; Web of Science; Scielo; Scopus; EMBASE; and Google Scholar with the use of predetermined keywords and Medical Subject Heading terms of the National Library of Medicine. Eight studies involving 182 mice and rats were included in the meta\u2010analysis. The results showed a significant reduction in the total number of inflammatory cells and in the isolated number of inflammatory cells, eosinophils, lymphocytes, macrophages and neutrophils (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). The results also revealed a significant decrease in the concentration of interleukins 13 and 33 in lung tissue. The present study demonstrated that prebiotic supplementation in the diet of rats and mice, as preclinical models, mitigates indicative parameters, inflammatory cells and interleukins, of allergic asthma induced by OVA, HDM or OVA + LPS. These beneficial results encourage randomized clinical trials to be carried out aiming at the prevention\/treatment of allergic asthma. \u00a9 2025 Society of Chemical Industry.\n                  <\/jats:p>","DOI":"10.1002\/jsfa.14325","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T03:45:18Z","timestamp":1746848718000},"page":"7619-7631","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prebiotics improve parameters indicative of allergy\u2010induced asthma in murines: a systematic review with meta\u2010analysis"],"prefix":"10.1002","volume":"105","author":[{"given":"Ricardo Augusto","family":"Silva","sequence":"first","affiliation":[{"name":"Food, Nutrition and Basic, Experimental and Clinical Health Research Group, Department of Functional Sciences, Faculty of Medicine Western S\u00e3o Paulo University (UNOESTE)  S\u00e3o Paulo 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