{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T07:12:41Z","timestamp":1758093161725,"version":"3.44.0"},"reference-count":47,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32402937"],"award-info":[{"award-number":["32402937"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2408085MC054"],"award-info":[{"award-number":["2408085MC054"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Many Chinese patent drug and Chinese herbal formulas containing <jats:italic>Paris polyphylla<\/jats:italic> Smith var. <jats:italic>chinensis<\/jats:italic> are frequently utilized as complementary treatments in cancer, aiming to enhance efficacy and mitigate adverse reactions. Recent studies highlight the crucial function of herbal polysaccharides in anti\u2010tumor and immunomodulation activity. Yet, the specific impact of polysaccharides from <jats:italic>Paris polyphylla<\/jats:italic> (PPP) on tumor and immunity remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The molecular weight of PPP was 10\u2009692\u2009Da. Furthermore, PPP is comprised of 10.29% mannose, 76.96% glucose, 7.26% galactose, and 5.49% arabinose. PPP significantly curtailed tumor proliferation in S180 tumor bearing mice. It not only enhanced the proliferation and cytotoxic T lymphocyte (CTL) activity of splenocytes in these mice but also boosted the secretion of cytokines. PPP administration also led to an increased messenger RNA expression of Th1 cytokines (IL\u20102) and transcription factors (T\u2010bet and STAT4) in their splenocytes. Additionally, PPP enhances the expression of Th2 cytokines (IL\u20104) and their associated transcription factors (GATA3 and STAT6) in the S180 tumor\u2010bearing model. Moreover, PPP enhanced the secretion of inflammatory factors and chemokines in tumor tissues. Moreover, PPP markedly elevated the protein expression of Caspase 3 and Caspase 8 in tumor tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>PPP effectively suppressed tumor growth by inducing balanced Th1\/Th2 immune response, and reconstructing the tumor immune microenvironment in S180 tumor bearing mice. \u00a9 2025 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.14415","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:14:21Z","timestamp":1748909661000},"page":"7169-7182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti\u2010tumor and immunomodulation activity of polysaccharide from <scp><i>Paris polyphylla<\/i><\/scp> Smith var. <i>chinensis<\/i> in <scp>S180<\/scp> tumor\u2010bearing mice"],"prefix":"10.1002","volume":"105","author":[{"given":"Hongyun","family":"Song","sequence":"first","affiliation":[{"name":"College of Pharmacy Anhui University of Chinese Medicine  Hefei China"},{"name":"College of Biotechnology and Pharmaceutical Engineering West Anhui University  Lu'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanbo","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Biotechnology and Pharmaceutical Engineering West Anhui University  Lu'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy Anhui University of Chinese Medicine  Hefei China"},{"name":"College of Biotechnology and Pharmaceutical Engineering West Anhui University  Lu'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qun","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Biotechnology and Pharmaceutical Engineering West Anhui University  Lu'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8822-4951","authenticated-orcid":false,"given":"Yanfei","family":"He","sequence":"additional","affiliation":[{"name":"College of Biotechnology and Pharmaceutical Engineering West Anhui University  Lu'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.07.042"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2019.11.010"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2019.08.022"},{"volume-title":"Pharmacopoeia of the People's Republic of China, Volume I","year":"2020","author":"Chinese Pharmacopoeia Commission","key":"e_1_2_10_6_1"},{"key":"e_1_2_10_7_1","unstructured":"ZuoY\u2010T Antitumor Constituents from Paris Polyphylla Smith Var. Yunnanensis. Tianjin Univ (2005)."},{"key":"e_1_2_10_8_1","first-page":"961","article-title":"Study on the antifertility effect of the saponins in rhizoma paridis yunnanensis [rhizoma from Prais polyphylla Smith var. yunnanensis (Franch) hand. \u2010Mazz.] in vitro","volume":"27","author":"Shen F","year":"2010","journal-title":"Chin J Mod Appl Pharm"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2012.07.007"},{"key":"e_1_2_10_10_1","first-page":"86","article-title":"Observations on the therapeutic effect of Loulian capsules in the treatment of hepatocellular carcinoma","volume":"18","author":"Wang RS","year":"2006","journal-title":"Chin Community Physicians"},{"key":"e_1_2_10_11_1","first-page":"69","article-title":"Inhibitory effect of \u201cJinfukang Decoction\u201d on growth of subgroup Sca\u20101+ Lewis stem cells","volume":"49","author":"Xu WJ","year":"2015","journal-title":"Shanghai J Tradit Chin Med"},{"key":"e_1_2_10_12_1","first-page":"160","article-title":"Mechanism of jinfukang oral liquid in inducing apoptosis of non\u2010small cell lung cancer cell line A549","volume":"24","author":"Jiang YX","year":"2018","journal-title":"Chin J Exp Tradit Med Formulae"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.09.189"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chmed.2022.02.003"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fochx.2022.100235"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.10.025"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.108682"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16060895"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.06.100"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2023.105781"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118067"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/md21110556"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-022-02172-2"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.04.011"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.621813"},{"key":"e_1_2_10_26_1","article-title":"Immunosuppressive tumor microenvironment modulation by chemotherapies and targeted therapies to enhance immunotherapy effectiveness","volume":"11","author":"Barnestein R","year":"2022","journal-title":"Onco Targets Ther"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2015.1077191"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242417422"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.844142"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.155135"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-020-00228-x"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-021-06968-6"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12123586"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2024.02.001"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-017-9487-9_2"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115976"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0254-6272(15)30076-5"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0369-8114(01)00170-5"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27782"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14466"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-021-00588-9"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-36667-4_2"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-36667-4_3"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.137263"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2023.216263"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.193"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110143"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2024.106314"}],"container-title":["Journal of the Science of Food and Agriculture"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jsfa.14415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T08:35:34Z","timestamp":1758011734000},"score":1,"resource":{"primary":{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/10.1002\/jsfa.14415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,2]]},"references-count":47,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/jsfa.14415"],"URL":"https:\/\/doi.org\/10.1002\/jsfa.14415","archive":["Portico"],"relation":{},"ISSN":["0022-5142","1097-0010"],"issn-type":[{"type":"print","value":"0022-5142"},{"type":"electronic","value":"1097-0010"}],"subject":[],"published":{"date-parts":[[2025,6,2]]},"assertion":[{"value":"2025-01-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}