{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:06:05Z","timestamp":1790269565111,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["6242001"],"award-info":[{"award-number":["6242001"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Inflammatory bowel disease (IBD) is a chronic condition marked by recurring intestinal inflammation, leading to symptoms such as fatigue, diarrhea, and weight loss. Current treatments are limited, highlighting the need for new therapeutic strategies. \u03b2\u2010Carotene (BC), a natural antioxidant, has potential in managing colitis, but its low bioavailability limits its efficacy. This study evaluated a novel BC\u2010loaded sesame protein hydrolysate nanoparticles (BC\u2010SPH NPs) formulation to enhance BC bioavailability and therapeutic performance in a dextran sodium sulfate (DSS)\u2010induced colitis model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>BC\u2010SPH NPs showed an average size of 50.30\u2009\u00b1\u20090.43\u2009nm, an encapsulation efficiency of 75.23\u2009\u00b1\u20090.92%, a prolonged plasma residence profile, with a time to reach maximum plasma concentration (<jats:italic>T<\/jats:italic><jats:sub>max<\/jats:sub>) of 8\u2009h, and a peak plasma concentration of 64.982\u2009ng\u2009mL<jats:sup>\u22121<\/jats:sup>. Notably, the NPs enabled enhanced tissue distribution of BC to key tissues in rats including kidneys, liver, small intestine, and colon. In DSS\u2010induced colitis mice, BC\u2010SPH NPs significantly reduced disease activity index, improved body weight, preserved colon length and structure, and prevented inflammatory cell infiltration. Additionally, BC\u2010SPH NPs lowered serum interleukin\u20106 (IL\u20106), interleukin\u20101\u03b2 (IL\u20101\u03b2), and tumor necrosis factor alpha (TNF\u2010\u03b1), as well as colonic myeloperoxidase (MPO) activity and nitric oxide (NO) levels. Furthermore, BC\u2010SPH NPs up\u2010regulated tight junction proteins Claudin\u20101, ZO\u20101, and Occludin, indicating improved intestinal barrier integrity. In contrast, free BC provided only modest effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrates that BC\u2010SPH NPs substantially enhance the bioavailability and therapeutic effects of BC in DSS\u2010induced colitis compared to free BC. The nanoformulation effectively alleviates colitis symptoms, preserves intestinal integrity, and reduces inflammation, suggesting that BC\u2010SPH NPs represent a promising natural therapeutic option for the prevention and treatment of ulcerative colitis. \u00a9 2025 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.14438","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T11:06:15Z","timestamp":1749726375000},"page":"7369-7381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Enhancing \u03b2\u2010carotene bioavailability and protective effects for dextran sodium sulfate\u2010induced colitis with sesame protein hydrolysate nanoparticles"],"prefix":"10.1002","volume":"105","author":[{"given":"Dounya Zad","family":"Oumeddour","sequence":"first","affiliation":[{"name":"Key Laboratory of Geriatric Nutrition and Health Beijing Technology and Business 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