{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:53:29Z","timestamp":1780498409816,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,11,4]],"date-time":"2009-11-04T00:00:00Z","timestamp":1257292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2010,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>BACKGROUND:<\/jats:bold> In a previous study, lyophilised yam reduced brain amyloid \u03b2\u2010protein (A\u03b2) accumulation and improved the antioxidative defence system in senescence\u2010accelerated (SAMP8) mice. Therefore, the aim of this study was to investigate the hepatic protection of yam in the carbon tetrachloride\u2010induced hepatic fibrosis of rats. Hepatic fibrosis was induced in rats via intraperitoneal injections of CCl<jats:sub>4<\/jats:sub> at a dose of 1 mL kg<jats:sup>\u22121<\/jats:sup> body weight (BW) twice weekly for 8 weeks. Three groups of rats were gavaged daily with yams at doses of 0.5, 1 and 2 g kg<jats:sup>\u22121<\/jats:sup> BW for 8 weeks, respectively.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> Yam treatments significantly decreased the ratio of liver\/body weight, levels of \u03b3\u2010glutaminotranspeptidase (GGT), low\u2010density lipoprotein, and triglyceride in serum when compared with those administered CCl<jats:sub>4<\/jats:sub> alone. Treatment with yams significantly elevated antioxidant activities of glutathione peroxidase (GSH\u2010Px) and superoxidase dismutase (SOD) in livers. Microscopically, yam\u2010treated groups presented with low histoscores of CCl<jats:sub>4<\/jats:sub>\u2010induced liver injury and fibrosis. Additionally, yam treatment reduced the area of GGT\u2010positive foci and the index of proliferating cell nuclear antigen (PCNA) in liver.<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold> Daily administration of yam attenuates CCl<jats:sub>4<\/jats:sub>\u2010induced hepatic fibrosis in rats in a dose\u2010dependent manner; this attenuation may be related to the antioxidant properties of yams. Copyright \u00a9 2009 Society of Chemical Industry<\/jats:p>","DOI":"10.1002\/jsfa.3801","type":"journal-article","created":{"date-parts":[[2009,11,4]],"date-time":"2009-11-04T08:45:28Z","timestamp":1257324328000},"page":"161-167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Beneficial effects of yam on carbon tetrachloride\u2010induced hepatic fibrosis in rats"],"prefix":"10.1002","volume":"90","author":[{"given":"Yin\u2010Ching","family":"Chan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Chieh","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sin\u2010Yie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin\u2010Ling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You\u2010Cheng","family":"Hseu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiunn\u2010Wang","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,11,4]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"165","volume-title":"Advance in Yam Research","author":"Ozo ON","year":"1985"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X02000624"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0963-9969(00)00074-0"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(97)87266-3"},{"key":"e_1_2_6_6_2","first-page":"1","article-title":"Studies on the characters, production potential, phytochemical properties, and antioxidant effect of Dioscorea spp","volume":"48","author":"Liu SY","year":"1999","journal-title":"J Agric Res China"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf0345954"},{"key":"e_1_2_6_8_2","first-page":"646","article-title":"Effects of Taiwanese yam (Dioscorea japonica Thunb var","volume":"19","author":"Chen HL","year":"2003","journal-title":"pseudojaponica"},{"key":"e_1_2_6_9_2","first-page":"147","article-title":"Antioxidant activity of dioscorea and dehydroepiandrosterone (DHEA) in older humans","volume":"59","author":"Araghiniknam M","year":"1996","journal-title":"Pharmacol Lett"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2007.06.009"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/105.1.65"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700420104"},{"key":"e_1_2_6_13_2","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/S0021-9258(17)43327-8","article-title":"Oxygen\u2010 and carbon\u2010centered free radical formation during carbon tetrachloride metabolism. 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